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Anna M. Varizhuk
Researcher at Federal Biomedical Agency
Publications - 59
Citations - 723
Anna M. Varizhuk is an academic researcher from Federal Biomedical Agency. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 15, co-authored 47 publications receiving 539 citations. Previous affiliations of Anna M. Varizhuk include Engelhardt Institute of Molecular Biology & Peninsular Malaysia.
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Journal ArticleDOI
The expanding repertoire of G4 DNA structures
Anna M. Varizhuk,Dmitry S. Ischenko,Vladimir B. Tsvetkov,Roman A. Novikov,Nikolay A. Kulemin,Dmitry N. Kaluzhny,Maria Vlasenok,Vladimir Naumov,Igor P. Smirnov,Galina E. Pozmogova +9 more
TL;DR: It is suggested that, similar to classical G4s, imperfect G 4s could be considered as potential regulatory elements, pathology biomarkers and therapeutic targets, reflecting the enhanced sequential diversity of these motifs.
Journal ArticleDOI
Synthesis, characterization and in vitro activity of thrombin-binding DNA aptamers with triazole internucleotide linkages.
Anna M. Varizhuk,Vladimir B. Tsvetkov,Olga N. Tatarinova,Dmitry N. Kaluzhny,V. L. Florentiev,Edward N. Timofeev,Anna K. Shchyolkina,Olga F. Borisova,Igor P. Smirnov,S. L. Grokhovsky,Anton V. Aseychev,Galina E. Pozmogova +11 more
TL;DR: Due to their relatively high activity and the increased resistance to nuclease digestion imparted by the triazole internucleotide linkages, the novel aptamers are a promising alternative to known DNA-based anticoagulant agents.
Journal ArticleDOI
Synthesis of triazole-linked oligonucleotides with high affinity to DNA complements and an analysis of their compatibility with biosystems.
Anna M. Varizhuk,Anna M. Varizhuk,Dmitry N. Kaluzhny,Roman A. Novikov,Alexandr O. Chizhov,Igor P. Smirnov,A. N. Chuvilin,Olga N. Tatarinova,Gleb Y. Fisunov,Galina E. Pozmogova,V. L. Florentiev +10 more
TL;DR: These new oligonucleotide analogues with triazole internucleotide linkages with remote from the 3'-terminus were synthesized and their hybridization properties were studied, suggesting that they are among the most promising Triazole DNA mimics characterized to date.
Journal ArticleDOI
A new design for a green calcium indicator with a smaller size and a reduced number of calcium-binding sites
Natalia V. Barykina,Oksana M. Subach,Oksana M. Subach,Danila A. Doronin,Danila A. Doronin,Vladimir P. Sotskov,M. A. Roshchina,Tatiana A. Kunitsyna,Aleksey Malyshev,Ivan V. Smirnov,Asya M. Azieva,Ilya S. Sokolov,Kiryl D. Piatkevich,Mikhail S. Burtsev,Anna M. Varizhuk,Anna M. Varizhuk,Galina E. Pozmogova,Konstantin V. Anokhin,Konstantin V. Anokhin,Fedor V. Subach,Grigori Enikolopov +20 more
TL;DR: A novel design for a one-fluorophore-based GECI with two Ca2+-binding sites is described, called NTnC, which is inserted in the mNeonGreen fluorescent protein and has higher brightness and pH-stability in vitro compared with the standard G ECI GCaMP6s.
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Comparison of the 'chemical' and 'structural' approaches to the optimization of the thrombin-binding aptamer.
Olga N. Tatarinova,Vladimir B. Tsvetkov,Dmitry Basmanov,Nikolay A. Barinov,Igor P. Smirnov,Edward N. Timofeev,Dmitry N. Kaluzhny,A. N. Chuvilin,Dmitry V. Klinov,Anna M. Varizhuk,Galina E. Pozmogova +10 more
TL;DR: Two different approaches were used to improve stability, binding affinity and biological activity of a known thrombin-binding aptamer and their relative advantages and disadvantages as well as their potential in drug design and fundamental studies were analyzed.