Olga N. Tatarinova

TL;DR: Due to their relatively high activity and the increased resistance to nuclease digestion imparted by the triazole internucleotide linkages, the novel aptamers are a promising alternative to known DNA-based anticoagulant agents.

TL;DR: These new oligonucleotide analogues with triazole internucleotide linkages with remote from the 3'-terminus were synthesized and their hybridization properties were studied, suggesting that they are among the most promising Triazole DNA mimics characterized to date.

TL;DR: Two different approaches were used to improve stability, binding affinity and biological activity of a known thrombin-binding aptamer and their relative advantages and disadvantages as well as their potential in drug design and fundamental studies were analyzed.

TL;DR: Findings on the spatial organization of Alu repeats may provide insight into the mechanisms of genomic rearrangements which underlie many oncological and neurodegenerative diseases.

TL;DR: Data obtained by mass spectrometry, electrophoresis, TEM and AFM microscopy techniques, bacterial transformation, and real-time PCR provide evidence that ssDNA and plasmid DNA (pDNA) efficiently form complexes with nNi, and suggest that the complexes are necklace-type structures, in which nanoparticles are randomly distributed along the DNA chains, rather than highly entangled clot-types.