A
Aarthy C. Vallur
Researcher at Infectious Disease Research Institute
Publications - 23
Citations - 899
Aarthy C. Vallur is an academic researcher from Infectious Disease Research Institute. The author has contributed to research in topics: Visceral leishmaniasis & Antigen. The author has an hindex of 17, co-authored 22 publications receiving 781 citations. Previous affiliations of Aarthy C. Vallur include University of Florida & University of Washington.
Papers
More filters
Journal ArticleDOI
G quadruplexes are genomewide targets of transcriptional helicases XPB and XPD
TL;DR: The highly significant overlap of XPB and XPD binding sites with G4 motifs cannot be explained by GC-richness or parameters of the genomewide analysis, but instead suggests that these proteins are recruited to quadruplex structures that form in genomic DNA (G4 DNA).
Journal ArticleDOI
From mouse to man: safety, immunogenicity and efficacy of a candidate leishmaniasis vaccine LEISH-F3+GLA-SE.
Rhea N. Coler,Malcolm S. Duthie,Kimberly A. Hofmeyer,Jeffery Guderian,Lakshmi Jayashankar,Julie Vergara,Tom Rolf,Ayesha Misquith,John D. Laurance,Vanitha S. Raman,H. Remy Bailor,Natasha Dubois Cauwelaert,Steven J. Reed,Aarthy C. Vallur,Michelle Favila,Mark T. Orr,Jill A. Ashman,Prakash Ghosh,Dinesh Mondal,Steven G. Reed +19 more
TL;DR: The vaccine candidate was shown to be safe and induced a strong antigen‐specific immune response, as evidenced by cytokine and immunoglobulin subclass data, which provide a strong rationale for additional trials in Leishmania‐endemic countries in populations vulnerable to VL.
Journal ArticleDOI
G4 motifs correlate with promoter-proximal transcriptional pausing in human genes
Johanna Eddy,Aarthy C. Vallur,Sudir Varma,Hongfang Liu,William C. Reinhold,Yves Pommier,Nancy Maizels +6 more
TL;DR: Findings suggest potential roles for dynamic G4 DNA and G4 RNA structures in cis-regulation of pausing, and thus genome-wide regulation of gene expression, in human cells.
Journal ArticleDOI
Real-time PCR in detection and quantitation of Leishmania donovani for the diagnosis of Visceral Leishmaniasis patients and the monitoring of their response to treatment.
Faria Hossain,Prakash Ghosh,Md. Anik Ashfaq Khan,Malcolm S. Duthie,Aarthy C. Vallur,Alessandro Picone,Randall F. Howard,Steven G. Reed,Dinesh Mondal +8 more
TL;DR: The real time PCR assay developed offers a molecular tool for accurate detection of circulating L. donovani parasites in VL, PKDL and RVL patients, as well as being capable of assessing response to treatment, and represents an important contribution in efforts to eliminate VL.
Journal ArticleDOI
Development and Comparative Evaluation of Two Antigen Detection Tests for Visceral Leishmaniasis
Aarthy C. Vallur,Yeung L. Tutterrow,Raodoh Mohamath,Sowmya Pattabhi,Asrat Hailu,Asim Abdoun,Abdalla E. Ahmed,Maowia M. Mukhtar,Abdus Salam,Meirielly Lima Almeida,Roque P. Almeida,Dinesh Mondal,Audrey Albertini,H. W. Ghalib,Malcolm S. Duthie,Steven G. Reed +15 more
TL;DR: The ELISAs provide a non-invasive method to detect parasite antigens during acute infection and monitor its clearance upon cure, filling an unmet need in VL management.