K
Kimberly A. Hofmeyer
Researcher at Infectious Disease Research Institute
Publications - 15
Citations - 1224
Kimberly A. Hofmeyer is an academic researcher from Infectious Disease Research Institute. The author has contributed to research in topics: Cytotoxic T cell & T cell. The author has an hindex of 12, co-authored 14 publications receiving 1091 citations. Previous affiliations of Kimberly A. Hofmeyer include National Institutes of Health & Yeshiva University.
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Journal ArticleDOI
Gcn5 Promotes Acetylation, Eviction, and Methylation of Nucleosomes in Transcribed Coding Regions
TL;DR: Gcn5p, most likely in SAGA, stimulates modification and eviction of nucleosomes in transcribed coding sequences and promotes Pol II elongation in the ARG1 ORF and bulk histones.
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Phosphorylated Pol II CTD recruits multiple HDACs, including Rpd3C(S), for methylation-dependent deacetylation of ORF nucleosomes
Chhabi K. Govind,Chhabi K. Govind,Hongfang Qiu,Daniel S. Ginsburg,Chun Ruan,Kimberly A. Hofmeyer,Cuihua Hu,V. Swaminathan,Jerry L. Workman,Bing Li,Alan G. Hinnebusch +10 more
TL;DR: It is demonstrated that Rpd3, Hos2, and Hda1 have overlapping functions in deacetylating histones and suppressing cotranscriptional histone eviction and a strong correlation between increased acetylation and lower histone occupancy in HDA mutants implies that histone acetylations is important for nucleosome eviction.
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The contrasting role of B7-H3
TL;DR: One such receptor is identified, triggering receptor expressed on myeloid cell (TREM)-like transcript 2 (TLT-2, or TREML2), which binds B7-H3 and costimulates activation of CD8 T cells in particular.
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The PD-1/PD-L1 (B7-H1) pathway in chronic infection-induced cytotoxic T lymphocyte exhaustion
TL;DR: Blockade of the PD-1/PD-L1 pathway is able to restore functional capabilities to exhausted CTLs and early clinical trials have shown promise, and further research will reveal how chronic infection induces upregulation ofPD-1 on C TLs and PD-L 1 on antigen-presenting cells and other tissue cells.
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From mouse to man: safety, immunogenicity and efficacy of a candidate leishmaniasis vaccine LEISH-F3+GLA-SE.
Rhea N. Coler,Malcolm S. Duthie,Kimberly A. Hofmeyer,Jeffery Guderian,Lakshmi Jayashankar,Julie Vergara,Tom Rolf,Ayesha Misquith,John D. Laurance,Vanitha S. Raman,H. Remy Bailor,Natasha Dubois Cauwelaert,Steven J. Reed,Aarthy C. Vallur,Michelle Favila,Mark T. Orr,Jill A. Ashman,Prakash Ghosh,Dinesh Mondal,Steven G. Reed +19 more
TL;DR: The vaccine candidate was shown to be safe and induced a strong antigen‐specific immune response, as evidenced by cytokine and immunoglobulin subclass data, which provide a strong rationale for additional trials in Leishmania‐endemic countries in populations vulnerable to VL.