Abhinav Kumar

TL;DR: The RISP-loaded SLN systems were stable and had high EE and similar shape to the placebo formulations before and after storage, and the viability of SLN as formulations for oral delivery of poorly water-soluble drugs such as RISP was illustrated.

TL;DR: This study demonstrates that dose correction using the ISDD model is essential for accurate interpretation of results derived from in vitro particle-cell interaction studies (e.g. particle uptake, cytotoxicity, mechanisms of action, pharmacodynamic studies, etc.).

TL;DR: Functional protein classification supports the hypothesis that corona formation in RTLF constitutes opsonisation, preparing particles for phagocytosis and clearance from the lungs, and highlights how an understanding of the evolved corona is necessary for the design of inhaled nanomedicines with acceptable safety and tailored clearance profiles.

TL;DR: The SLF reported herein constitutes a biorelevant synthetic simulant which is suitable to studyBiopharmaceutical properties of inhalation medicines such as those being proposed for an inhaled biopharmaceutics classification system.

TL;DR: At minimally cytotoxic doses both DEP and BAD perturbed bacterial clearance and promoted inflammatory responses in U937 cells with similar potency, which emphasise the requirement to consider contributions of abrasion particles to traffic-related clinical health effects.