T
Timothy W. Gant
Researcher at Public Health England
Publications - 143
Citations - 6516
Timothy W. Gant is an academic researcher from Public Health England. The author has contributed to research in topics: Gene expression & Gene. The author has an hindex of 43, co-authored 133 publications receiving 5892 citations. Previous affiliations of Timothy W. Gant include King's College London & University of London.
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Journal ArticleDOI
Circadian Cycling of the Mouse Liver Transcriptome, as Revealed by cDNA Microarray, Is Driven by the Suprachiasmatic Nucleus
Ruth Akhtar,Akhilesh B. Reddy,Elizabeth S. Maywood,Jonathan D. Clayton,Verdun M. King,Andrew G. Smith,Timothy W. Gant,Michael H. Hastings,Charalambos P. Kyriacou +8 more
TL;DR: Temporally complex, circadian programming of the transcriptome in a peripheral organ is imposed across a wide range of core cellular functions and is dependent on an interaction between intrinsic, tissue-specific factors and extrinsic regulation by the SCN central pacemaker.
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Adenovirus-mediated in vivo gene transfer and expression in normal rat liver.
H A Jaffe,Claire Danel,Glenn Longenecker,Metzger M,Yasuhiro Setoguchi,Melissa A. Rosenfeld,Timothy W. Gant,Snorri S. Thorgeirsson,L D Stratford-Perricaudet,Michel Perricaudet +9 more
TL;DR: Targeted gene expression has been achieved in the liver, albeit at low levels, suggesting that adenovirus vectors may be a useful means for in vivo gene therapy in liver disorders.
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Redox cycling and sulphydryl arylation; Their relative importance in the mechanism of quinone cytotoxicity to isolated hepatocytes
TL;DR: While oxidative processes may cause toxicity, the arylation of intracellular thiols or nucleophiles also contributes significantly to the cytotoxicity of compounds such as menadione.
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Smoking induces differential miRNA expression in human spermatozoa: A potential transgenerational epigenetic concern?
TL;DR: It is shown that cigarette smoke induces specific differences in the spermatozoal microRNA content of human smokers compared with non-smokers, and that these altered microRNAs appear to predominantly mediate pathways vital for healthy sperm and normal embryo development, particularly cell death and apoptosis.
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Lysine-Specific Demethylase 1 Regulates the Embryonic Transcriptome and CoREST Stability
Charles T. Foster,Oliver M. Dovey,Larissa Lezina,Jin Li Luo,Timothy W. Gant,Nick Barlev,Allan Bradley,Shaun M. Cowley +7 more
TL;DR: Lysine-specific demethylase 1 regulates the expression and appropriate timing of key developmental regulators, as part of the LSD1/CoREST/HDAC complex, during early embryonic development.