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Achim Aigner
Researcher at Leipzig University
Publications - 185
Citations - 9397
Achim Aigner is an academic researcher from Leipzig University. The author has contributed to research in topics: Small interfering RNA & Gene knockdown. The author has an hindex of 48, co-authored 164 publications receiving 8413 citations. Previous affiliations of Achim Aigner include University of Washington & University of Marburg.
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RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo
TL;DR: It is shown that the noncovalent complexation of synthetic siRNAs with low molecular weight polyethylenimine (PEI) efficiently stabilizes si RNAs and delivers siRNas into cells where they display full bioactivity at completely nontoxic concentrations.
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Identification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophin.
Gerald E. Stoica,Angera H. Kuo,Achim Aigner,Iruvanti Sunitha,Boussad Souttou,Claudius Malerczyk,Dana J. Caughey,Duanzhi Wen,Alex Karavanov,Anna T. Riegel,Anton Wellstein +10 more
TL;DR: It is proposed that the PTN-ALK axis can play a significant role during development and during disease processes because of the growth stimulatory effect of PTN on different cell lines in culture coincides with the endogenous expression of ALK mRNA.
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MicroRNA replacement therapy for miR-145 and miR-33a is efficacious in a model of colon carcinoma
Ahmed Fawzy Ibrahim,Ulrike Weirauch,Maren Thomas,Arnold Grünweller,Roland K. Hartmann,Achim Aigner +5 more
TL;DR: Findings show that chemically unmodified miRNAs complexed with PEI can be used in an efficient and biocompatible strategy of miRNA replacement therapy, as illustrated by efficacious delivery of PEI/miR-145 and PEI-complexed miR-33a complexes in colon carcinoma.
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Poly(vinyl alcohol) nanofibers by electrospinning as a protein delivery system and the retardation of enzyme release by additional polymer coatings.
TL;DR: This preservation of enzyme activity and the continuous release of the intact enzyme from the immersed fibers meets a fundamental prerequisite for the application of enzymes or other sensitive agents released from electrospun nanofibers under physiological conditions.