Adam C. Curry

TL;DR: Binding of streptavidin at 1 nM concentration induces a mean resonant wavelength shift of 0.59 nm suggesting that the current optical setup is able to reliably measure wavelength shifts as small as 0.3 nm, which is close to the limit of detection of the system.

TL;DR: An analytical model that can be used for the rational design of a biosensor based on shifts in the local surface plasmon resonance (LSPR) of individual gold nanoparticles was used to design an LSPR sensor based on biotin-functionalized gold nanorods that offers the lowest MDL for this class of sensors.

TL;DR: Using optical darkfield micro-spectroscopy to characterize the plasmon resonance of individual silver nanoparticles in the presence of a substrate, the optical system for characterizing nanoparticles attached to substrates for biosensing applications is discussed.

TL;DR: In this paper, diagnostic assays using surface enhanced Raman spectroscopy (SERS)-active particles, including liquid-based assays, magnetic capture assays; microparticle-nanoparticle satellite structures for signal amplification in an assay; composite SERS-active particles useful for enhanced detection of targets; and sample tubes and processes for using the same.

TL;DR: The intracellular refractive index (RI) within attoliter volumes inside of the living cells is determined through detailed analysis of the NP scattering spectra, suggesting that EGFR-mediated internalization of NPs may provide an advantage for maintaining NP isolation upon uptake.