A
Adam Cook
Researcher at University of Sydney
Publications - 22
Citations - 1112
Adam Cook is an academic researcher from University of Sydney. The author has contributed to research in topics: Chemistry & DNA repair. The author has an hindex of 10, co-authored 19 publications receiving 1012 citations. Previous affiliations of Adam Cook include Centre national de la recherche scientifique & Centenary Institute of Cancer Medicine and Cell Biology.
Papers
More filters
Journal ArticleDOI
Regulation of replication fork progression through histone supply and demand
TL;DR: It is proposed that Asf 1, as a histone acceptor and donor, handles parental and new histones at the replication fork via an Asf1–(H3-H4)–MCM2–7 intermediate and thus provides a means to fine-tune replication fork progression and histone supply and demand.
Journal ArticleDOI
HP1α recruitment to DNA damage by p150CAF-1 promotes homologous recombination repair
Céline Baldeyron,Gastón Soria,Gastón Soria,Danièle Roche,Danièle Roche,Adam Cook,Adam Cook,Geneviève Almouzni,Geneviève Almouzni +8 more
TL;DR: p150CAF-1-mediated recruitment of HP1α to DNA is essential for efficient assembly of DNA damage response complexes and subsequent homologous recombination repair.
Journal ArticleDOI
A Specific Function for the Histone Chaperone NASP to Fine-Tune a Reservoir of Soluble H3-H4 in the Histone Supply Chain
Adam Cook,Zachary A. Gurard-Levin,Zachary A. Gurard-Levin,Isabelle Vassias,Isabelle Vassias,Geneviève Almouzni,Geneviève Almouzni +6 more
TL;DR: The data suggest that NASP does so by balancing the activity of the heat shock proteins Hsc70 and Hsp90 to direct H3-H4 for degradation by chaperone-mediated autophagy, and the existence of a tunable reservoir in mammalian cells demonstrates that contingency is integrated into the histone supply chain to respond to unexpected changes in demand.
Journal ArticleDOI
The HP1–p150/CAF-1 interaction is required for pericentric heterochromatin replication and S-phase progression in mouse cells
TL;DR: It is shown that p150, a subunit of chromatin assembly factor 1, has a key role in the replication of pericentric heterochromatin and S-phase progression in mouse cells, independently of its known function in histone deposition.
Journal ArticleDOI
Reduced Switching in SCID B Cells Is Associated with Altered Somatic Mutation of Recombined S Regions
TL;DR: It is shown that switching to all isotypes examined was detectable when the SCID mutation was introduced into anti-hen egg lysozyme transgenic B cells capable of undergoing class switch recombination, but switching was significantly reduced in comparison with control B cells of the same specificity lacking the RAG1 gene.