Jean-Pierre Quivy

TL;DR: The results show that both H3-K9 acetylation and methylation can occur on independent sets of H3 molecules in pericentric heterochromatin, and identify an RNA- and histone modification–dependent structure that brings methylated H1 protein–binding tails together in a specific configuration required for the accumulation of HP1 proteins in these domains.

TL;DR: A nucleosome assembly pathway that depends on HIRA is delineated, and this defect was largely corrected by reintroduction of HIRA along with (H3-H4)(2) tetramers.

TL;DR: It is shown that the presence of single-strand breaks and gaps, formed either directly or during DNA damage processing, can trigger the propagation of nucleosomal arrays, which involves the histone chaperone chromatin assembly factor 1 (CAF-1).

TL;DR: The importance of histone chaperones during development is discussed and how misregulation of the histone flow can link to disease is described, to show how they affect dynamics during DNA replication, DNA damage, and transcription, and how they maintain genome integrity.

TL;DR: It is suggested that hAsf1 provides the cells with a buffering system for histone excess generated in response to stalled replication and explains how mammalian cells maintain a critical "active" histone pool available for deposition during recovery from replication stresses.