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Adèle Thomas
Researcher at Macquarie University
Publications - 23
Citations - 3044
Adèle Thomas is an academic researcher from Macquarie University. The author has contributed to research in topics: Cannabinoid & Cannabinoid receptor. The author has an hindex of 17, co-authored 23 publications receiving 2712 citations. Previous affiliations of Adèle Thomas include University of Aberdeen & University of Bristol.
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Journal ArticleDOI
Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro
TL;DR: This study aimed to investigate whether the properties of cannabidiol extend to CB1 receptors expressed in mouse brain and to human CB2 receptors that have been transfected into CHO cells.
Journal ArticleDOI
Peripheral cytokines profile in Parkinson's disease
Marcella Reale,Carla Iarlori,Adèle Thomas,Domenico Gambi,Bernardo Perfetti,M. Di Nicola,Marco Onofrj +6 more
TL;DR: Levels of production and expression of cyto/chemokines by PBMCs in PD patients are investigated to strengthen and extend the knowledge of the peripheral dysregulation in the cytokine network associated with PD.
Journal ArticleDOI
Allosteric Modulation of the Cannabinoid CB1 Receptor
Martin R. Price,Gemma L. Baillie,Adèle Thomas,Lesley A. Stevenson,Morag Easson,Richard Goodwin,Adèle McLean,Lorraine McIntosh,Gillian Goodwin,Glenn Walker,Paul Westwood,Julia Marrs,Fiona Thomson,Phillip M. Cowley,Arthur Christopoulos,Roger G. Pertwee,Ruth A. Ross +16 more
TL;DR: The data presented clearly demonstrate, for the first time, that the cannabinoid CB1 receptor contains an allosteric binding site that can be recognized by synthetic small molecule ligands.
Journal Article
Duration of amantadine benefit on dyskinesia of severe Parkinson’s disease
TL;DR: 300 mg amantadine reduces dyskinesia in Parkinson's disease by approximately 45% but the benefit lasted less than eight months.
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Exercise for vasomotor menopausal symptoms
TL;DR: Examination of the effectiveness of any type of exercise intervention in the management of vasomotor symptoms in symptomatic perimenopausal and postmenopausal women found insufficient to show whether exercise is an effective treatment for vasom motor symptoms.