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Gemma L. Baillie
Researcher at University of Toronto
Publications - 18
Citations - 2113
Gemma L. Baillie is an academic researcher from University of Toronto. The author has contributed to research in topics: Cannabinoid & Allosteric regulation. The author has an hindex of 13, co-authored 18 publications receiving 1832 citations. Previous affiliations of Gemma L. Baillie include Centre for Addiction and Mental Health & University of Aberdeen.
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Journal ArticleDOI
Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro
TL;DR: This study aimed to investigate whether the properties of cannabidiol extend to CB1 receptors expressed in mouse brain and to human CB2 receptors that have been transfected into CHO cells.
Journal ArticleDOI
Allosteric Modulation of the Cannabinoid CB1 Receptor
Martin R. Price,Gemma L. Baillie,Adèle Thomas,Lesley A. Stevenson,Morag Easson,Richard Goodwin,Adèle McLean,Lorraine McIntosh,Gillian Goodwin,Glenn Walker,Paul Westwood,Julia Marrs,Fiona Thomson,Phillip M. Cowley,Arthur Christopoulos,Roger G. Pertwee,Ruth A. Ross +16 more
TL;DR: The data presented clearly demonstrate, for the first time, that the cannabinoid CB1 receptor contains an allosteric binding site that can be recognized by synthetic small molecule ligands.
Journal ArticleDOI
Pregnenolone Can Protect the Brain from Cannabis Intoxication
Monique Vallée,Monique Vallée,S. Vitiello,S. Vitiello,Luigi Bellocchio,Luigi Bellocchio,Etienne Hebert-Chatelain,Etienne Hebert-Chatelain,Stéphanie Monlezun,Elena Martín-García,Fernando Kasanetz,Fernando Kasanetz,Gemma L. Baillie,Francesca Panin,Francesca Panin,Adeline Cathala,Adeline Cathala,Valérie Roullot-Lacarrière,Valérie Roullot-Lacarrière,Sandy Fabre,Dow P. Hurst,Diane L. Lynch,Derek M. Shore,Véronique Deroche-Gamonet,Véronique Deroche-Gamonet,Umberto Spampinato,Umberto Spampinato,Jean-Michel Revest,Jean-Michel Revest,Rafael Maldonado,Patricia H. Reggio,Ruth A. Ross,Giovanni Marsicano,Giovanni Marsicano,Pier Vincenzo Piazza,Pier Vincenzo Piazza +35 more
TL;DR: Positive feedback mediated by pregnenolone reveals a previously unknown paracrine/autocrine loop protecting the brain from CB1 receptor overactivation that could open an unforeseen approach for the treatment of cannabis intoxication and addiction.
Journal ArticleDOI
Evidence that the plant cannabinoid Δ9-tetrahydrocannabivarin is a cannabinoid CB1 and CB2 receptor antagonist
Adèle Thomas,Lesley A. Stevenson,Kerrie N. Wease,Martin F. Price,Gemma L. Baillie,Ruth A. Ross,Roger G. Pertwee +6 more
TL;DR: In the vas deferens, THCV antagonized several cannabinoids more potently than THC and was also more potent against CP55940 and R‐(+)‐WIN55212 in this tissue than in brain membranes, behaving as a competitive CB1 and CB2 receptor antagonist.
Journal ArticleDOI
A Cannabinoid CB1 Receptor Positive Allosteric Modulator Reduces Neuropathic Pain in the Mouse with no Psychoactive Effects
Bogna M. Ignatowska-Jankowska,Gemma L. Baillie,Steven G. Kinsey,Molly S. Crowe,Sudeshna Ghosh,Robert A. Owens,Damaj Imad M,Justin L. Poklis,Jenny L. Wiley,Matteo Zanda,Chiara Zanato,Iain R. Greig,Aron H. Lichtman,Ruth Alexandra Ross +13 more
TL;DR: The development of the novel synthetic CB1 PAM, 6-methyl-3-(2-nitro-1-(thiophen-2-yl)ethyl)-2-phenyl-1H-indole (ZCZ011), is described, which augments the in vitro and in vivo pharmacological actions of the CB1 orthosteric agonists CP55,940 and N-arachidonoylethanolamine (AEA).