A
Aditya Parekh
Researcher at Indian Institute of Technology Kharagpur
Publications - 18
Citations - 645
Aditya Parekh is an academic researcher from Indian Institute of Technology Kharagpur. The author has contributed to research in topics: Cancer & Breast cancer. The author has an hindex of 11, co-authored 16 publications receiving 440 citations. Previous affiliations of Aditya Parekh include Indian Institutes of Technology.
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Journal ArticleDOI
Exosome as a Novel Shuttle for Delivery of Therapeutics across Biological Barriers.
Chandan Kanta Das,Bikash Chandra Jena,Indranil Banerjee,Subhayan Das,Aditya Parekh,Sujit K. Bhutia,Mahitosh Mandal +6 more
TL;DR: The current status of exosome as a delivery vehicle for therapeutics and the challenges that need to be overcome are covered, and the future perspectives of this exciting field of research are discussed to transform it from bench to clinical reality.
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Molecular targeting of Akt by thymoquinone promotes G1 arrest through translation inhibition of cyclin D1 and induces apoptosis in breast cancer cells
Shashi Rajput,B. N. Prashanth Kumar,Kaushik Kumar Dey,Ipsita Pal,Aditya Parekh,Mahitosh Mandal +5 more
TL;DR: TQ's mechanism of action against PI3K/Akt signaling and its downstream targets is investigated by modulating proteins translational machinery, leading to apoptosis in cancer cells, thus ratifying the involvement of Akt in apoptosis.
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Lactate dehydrogenase A regulates autophagy and tamoxifen resistance in breast cancer.
TL;DR: This study revealed that LDHA; one of the key molecules of glycolysis in association with Beclin-1 induced pro-survival autophagy in tamoxifen-resistant breast cancer.
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Celecoxib alleviates tamoxifen-instigated angiogenic effects by ROS-dependent VEGF/VEGFR2 autocrine signaling
B. N. Prashanth Kumar,Shashi Rajput,Kaushik Kumar Dey,Aditya Parekh,Subhasis Das,Abhijit Mazumdar,Mahitosh Mandal +6 more
TL;DR: This work elucidated how the combination of TAM and CXB at nontoxic doses exerts anti-angiogenic effects by specifically targeting VEGF/VEGFR2 autocrine signaling through ROS generation and indicates that this additive combination shows promising outcome in anti-metastatic and apoptotic studies.
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Gold nanorod embedded reduction responsive block copolymer micelle-triggered drug delivery combined with photothermal ablation for targeted cancer therapy.
Sheetal Parida,Chiranjit Maiti,Y. Rajesh,Kaushik Kumar Dey,Ipsita Pal,Aditya Parekh,Rusha Patra,Dibakar Dhara,Pranab K. Dutta,Mahitosh Mandal +9 more
TL;DR: This work designs unique, multifunctional, gold nanorod embedded block copolymer micelle loaded with GW627368X for targeted drug delivery and photothermal therapy and combination of the two modalities enhances therapeutic efficacy by inducing both forms of cell death.