A
Adrian J. Williams
Researcher at Guy's and St Thomas' NHS Foundation Trust
Publications - 93
Citations - 6267
Adrian J. Williams is an academic researcher from Guy's and St Thomas' NHS Foundation Trust. The author has contributed to research in topics: Polysomnography & Narcolepsy. The author has an hindex of 28, co-authored 91 publications receiving 5636 citations. Previous affiliations of Adrian J. Williams include King's College London & St Thomas' Hospital.
Papers
More filters
Journal ArticleDOI
International multicenter pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson's disease : The NMSQuest study
Kallol Ray Chaudhuri,Pablo Martinez-Martin,Anthony H.V. Schapira,Fabrizio Stocchi,Kapil D. Sethi,Per Odin,Richard G. Brown,W. C. Koller,Paolo Barone,Graeme Macphee,Linda Kelly,Martin Rabey,Doug MacMahon,Sue Thomas,William G. Ondo,David B. Rye,A Forbes,S. Tluk,Vandana Dhawan,A Bowron,Adrian J. Williams,C. W. Olanow +21 more
TL;DR: An international pilot study assessing feasibility, validity, and acceptability of a nonmotor questionnaire (NMSQuest) found NMS were highly significantly more prevalent across all disease stages and the number of symptoms correlated significantly with advancing disease and duration of disease.
Journal ArticleDOI
The metric properties of a novel non-motor symptoms scale for Parkinson's disease: Results from an international pilot study.
Kallol Ray Chaudhuri,Pablo Martinez-Martin,Richard G. Brown,Kapil D. Sethi,Fabrizio Stocchi,Per Odin,William G. Ondo,Kazuo Abe,Graeme Macphee,Doug MacMahon,Paolo Barone,Martin Rabey,A Forbes,Kieran Breen,S. Tluk,Y. Naidu,Warren Olanow,Adrian J. Williams,Sue Thomas,David B. Rye,Yoshio Tsuboi,Annette Hand,Anthony H.V. Schapira,Anthony H.V. Schapira +23 more
TL;DR: NMSS can be used to assess the frequency and severity of NMS in PD patients across all stages in conjunction with the recently validated non‐motor questionnaire.
Journal ArticleDOI
A length polymorphism in the circadian clock gene Per3 is linked to delayed sleep phase syndrome and extreme diurnal preference.
Simon Archer,Donna L Robilliard,Debra J. Skene,Marcel Smits,Adrian J. Williams,Josephine Arendt,Malcolm von Schantz +6 more
TL;DR: The length of the Per3 repeat region identifies a potential genetic marker for extreme diurnal preference and was strongly associated with the delayed sleep phase syndrome patients, 75% of whom were homozygous.
A Length Polymorphism in the Circadian Clock Gene Per3 is Linked to Delayed Sleep Phase Syndrome and Extreme Diurnal Preference CIRCADIAN RHYTHMS
Simon Archer,Donna L Robilliard,Debra J. Skene,Marcel Smits,Adrian J. Williams,Josephine Arendt,Malcolm von Schantz,Guildford Gu +7 more
TL;DR: In this paper, the authors investigated the link between extreme diurnal preference, delayed sleep phase syndrome, and a length polymorphism in Per3 and found that the longer allele associated with morningness and the shorter allele with eveningness.
Journal ArticleDOI
Prevalence of nonmotor symptoms in Parkinson's disease in an international setting; Study using nonmotor symptoms questionnaire in 545 patients
Pablo Martinez-Martin,Anthony H.V. Schapira,Fabrizio Stocchi,Kapil D. Sethi,Per Odin,Graeme Macphee,Richard G. Brown,Y. Naidu,Lisa Clayton,Kazuo Abe,Yoshio Tsuboi,Dough MacMahon,Paolo Barone,Martin Rabey,Ubaldo Bonuccelli,A Forbes,Kieran Breen,S. Tluk,C. Warren Olanow,Sue Thomas,David B. Rye,Annette Hand,Adrian J. Williams,William G. Ondo,K. Ray Chaudhuri +24 more
TL;DR: The results gathered from 545 patients using the definitive version of the NMSQuest are presented highlighting the prevalence of the wide range of NMS flagged in the N MSQuest from consecutive PD patients in an international setting.