D
David B. Rye
Researcher at Emory University
Publications - 167
Citations - 13568
David B. Rye is an academic researcher from Emory University. The author has contributed to research in topics: Restless legs syndrome & Polysomnography. The author has an hindex of 54, co-authored 166 publications receiving 12385 citations. Previous affiliations of David B. Rye include Emory Healthcare.
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Journal ArticleDOI
Nuclear and Neuropil Aggregates in Huntington’s Disease: Relationship to Neuropathology
Claire-Anne Gutekunst,Shihua Li,Hong Yi,James S. Mulroy,Stefan Kuemmerle,Randi Jones,David B. Rye,Robert J. Ferrante,Steven M. Hersch,Xiao-Jiang Li +9 more
TL;DR: It is shown that neuropil aggregates are much more common than nuclear aggregates and can be present in large numbers before the onset of clinical symptoms, suggesting that they may persist in neurons that are more likely to survive.
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International multicenter pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson's disease : The NMSQuest study
Kallol Ray Chaudhuri,Pablo Martinez-Martin,Anthony H.V. Schapira,Fabrizio Stocchi,Kapil D. Sethi,Per Odin,Richard G. Brown,W. C. Koller,Paolo Barone,Graeme Macphee,Linda Kelly,Martin Rabey,Doug MacMahon,Sue Thomas,William G. Ondo,David B. Rye,A Forbes,S. Tluk,Vandana Dhawan,A Bowron,Adrian J. Williams,C. W. Olanow +21 more
TL;DR: An international pilot study assessing feasibility, validity, and acceptability of a nonmotor questionnaire (NMSQuest) found NMS were highly significantly more prevalent across all disease stages and the number of symptoms correlated significantly with advancing disease and duration of disease.
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The metric properties of a novel non-motor symptoms scale for Parkinson's disease: Results from an international pilot study.
Kallol Ray Chaudhuri,Pablo Martinez-Martin,Richard G. Brown,Kapil D. Sethi,Fabrizio Stocchi,Per Odin,William G. Ondo,Kazuo Abe,Graeme Macphee,Doug MacMahon,Paolo Barone,Martin Rabey,A Forbes,Kieran Breen,S. Tluk,Y. Naidu,Warren Olanow,Adrian J. Williams,Sue Thomas,David B. Rye,Yoshio Tsuboi,Annette Hand,Anthony H.V. Schapira,Anthony H.V. Schapira +23 more
TL;DR: NMSS can be used to assess the frequency and severity of NMS in PD patients across all stages in conjunction with the recently validated non‐motor questionnaire.
Journal ArticleDOI
Localization of D1 and D2 dopamine receptors in brain with subtype-specific antibodies.
Allan I. Levey,Steven M. Hersch,David B. Rye,Roger K. Sunahara,Hyman B. Niznik,Cheryl A. Kitt,Donald L. Price,Roberto Maggio,Mark R. Brann,Brian J. Ciliax +9 more
TL;DR: Results provide a morphological substrate for understanding the pre- and postsynaptic functions of the genetically defined D1 and D2 receptors in discrete neuronal circuits in mammalian brain.
Journal ArticleDOI
A genetic risk factor for periodic limb movements in sleep
Hreinn Stefansson,David B. Rye,Andrew A. Hicks,H. Petursson,Andres Ingason,Thorgeir E. Thorgeirsson,Stefan T Palsson,Thordur Sigmundsson,Albert P. Sigurdsson,Ingibjorg Eiriksdottir,Emilia Soebech,Donald L. Bliwise,Joseph M. Beck,Ami Rosen,Salina P. Waddy,Lynn Marie Trotti,Alex Iranzo,Madhav Thambisetty,Gudmundur A. Hardarson,Kristleifur Kristjansson,Larus J. Gudmundsson,Unnur Thorsteinsdottir,Augustine Kong,Jeffrey R. Gulcher,Daniel F. Gudbjartsson,Kari Stefansson +25 more
TL;DR: The inverse correlation of the variant with iron stores is consistent with the suspected involvement of iron depletion in the pathogenesis of the disease and is associated with susceptibility to periodic limb movements in sleep.