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Adrian T. Keatinge-Clay
Researcher at University of Texas at Austin
Publications - 70
Citations - 3280
Adrian T. Keatinge-Clay is an academic researcher from University of Texas at Austin. The author has contributed to research in topics: Polyketide & Polyketide synthase. The author has an hindex of 30, co-authored 65 publications receiving 2891 citations. Previous affiliations of Adrian T. Keatinge-Clay include Brown University & University of California, San Francisco.
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A Tylosin Ketoreductase Reveals How Chirality Is Determined in Polyketides
TL;DR: The structure of KR from the first module of the tylosin PKS was determined and reveals how polyketides are guided into the active site by key residues in different KR types.
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The structures of type I polyketide synthases
TL;DR: This review highlights not only what has been revealed about the structures and activities of each of the domains of type I polyketide synthases but also the mysteries that remain to be solved.
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The structure of a ketoreductase determines the organization of the beta-carbon processing enzymes of modular polyketide synthases
TL;DR: The quaternary structure elucidates how substrates are shuttled between the active sites of polyketide synthases, as well as related fatty acid synthases (FASs), and suggests how domains can be swapped to make hybrid synthases that produce novel polyketides.
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High-resolution macromolecular NMR spectroscopy inside living cells.
Zach Serber,Adrian T. Keatinge-Clay,Richard Ledwidge,Alexander E. Kelly,Susan M. Miller,Volker Dötsch +5 more
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Crystal structure of the erythromycin polyketide synthase dehydratase.
TL;DR: The structure elucidates how the alpha-hydrogen and beta-hydroxyl group of a polyketide substrate interact with the catalytic histidine and aspartic acid in the DH active site prior to dehydration.