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Showing papers by "Adriana Bolasco published in 2013"

Journal Article•DOI•
Synthesis and cytotoxicity of novel (thiazol-2-yl)hydrazine derivatives as promising anti-Candida agents.

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Simone Carradori1, Daniela Secci1, Adriana Bolasco1, Daniela Rivanera1, Emanuela Mari1, Alessandra Zicari1, Lavinia Vittoria Lotti1, Bruna Bizzarri1 •
Sapienza University of Rome1
01 Jul 2013-European Journal of Medicinal Chemistry
TL;DR: The concurrent presence of aliphatic chains or cycloaliphatic rings at N1-hydrazine and a 4-methyl/4-methoxyphenyl at C4 position of the thiazole nucleus exhibited an interesting anti-Candida inhibitory activity.

42 citations

Journal Article•DOI•
Conventional and Microwave‐Assisted Synthesis of Benzimidazole Derivatives and Their in vitro Inhibition of Human Cyclooxygenase.

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Daniela Secci1, Adriana Bolasco1, Melissa D'Ascenzio1, Flavio della Sala1, Matilde Yáñez1, Simone Carradori1 •
Sapienza University of Rome1
23 Apr 2013-ChemInform
TL;DR: Using a microwave-assisted oxidative cyclization procedure, a large series of benzimidazole derivatives is prepared and evaluated for their ability to inhibit human cyclooxygenases.
Abstract: Using a novel microwave-assisted oxidative cyclization procedure, a large series of benzimidazole derivatives is prepared and evaluated for their ability to inhibit human cyclooxygenases.
Journal Article•DOI•
Synthesis and Selective Inhibitory Activity Against Human COX‐1 of Novel 1‐(4‐Substituted‐thiazol‐2‐yl)‐3,5‐di(hetero)aryl‐pyrazoline Derivatives.

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Simone Carradori1, Daniela Secci1, Adriana Bolasco1, Celeste De Monte1, Matilde Yáñez1 •
Sapienza University of Rome1
09 Apr 2013-ChemInform
TL;DR: New pyrazoline derivatives (Vc, Vd, Vf, Vh) showed promising inhibitory activities against human cyclooxygenase-1 in the micromolar range, similar or better than the reference drugs indometacin and diclofenac.
Abstract: New pyrazoline derivatives (Vc), (Vd), (Vf)—(Vh) display promising inhibitory activities against human cyclooxygenase-1 in the micromolar range, similar or better than the reference drugs indometacin and diclofenac.