Adriana Cristina Mancin

TL;DR: This is the first report on the structure of a toxin from snake venom active on Na+ channel determined by proton NMR spectroscopy and it is suggested to exhibit analgesic activity and to be myonecrotic.

TL;DR: Crotamine induced a time-dose dependent analgesic effect which was inhibited by naloxone, thus suggesting an opioid action mechanism, and was identified as its major antinociceptive low molecular weight peptide component from Crotalus durissus venom.

TL;DR: Data indicate that enzymatic activity is relevant for some pharmacological effects induced by crotoxin B (mainly lethal, myotoxic and anticoagulant activities), and also evidence that this subunit of crot toxin displays regions different from the active catalytic site which are involved in some of the toxic and pharmacological results induced by this phospholipase A(2).

TL;DR: Doses up to 5 LD50 of p-bromophenacyl bromide alkylated BnSP-7 caused a total loss of lethality in 18-22-g mice, thus indicating that the LD50 was increased by greater than 5-fold.

TL;DR: The findings suggest that the action of these agents during histamine release may involve the participation of specific intermediary hydrolases which, upon activation, would enhance their cytolytic effects on the sequence of events which lead to granule extrusion and histamines release from mast cells.