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Adriana Svrlanska
Researcher at University of Erlangen-Nuremberg
Publications - 6
Citations - 78
Adriana Svrlanska is an academic researcher from University of Erlangen-Nuremberg. The author has contributed to research in topics: Viral replication & Lytic cycle. The author has an hindex of 5, co-authored 6 publications receiving 45 citations.
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Journal ArticleDOI
Protein kinases responsible for the phosphorylation of the nuclear egress core complex of human cytomegalovirus.
Eric Sonntag,Jens Milbradt,Adriana Svrlanska,Hanife Strojan,Sigrun Häge,Alexandra Kraut,Anne-Marie Hesse,Bushra Amin,Bushra Amin,Uwe Sonnewald,Yohann Couté,Manfred Marschall +11 more
TL;DR: These findings provide the first evidence that the HCMV core NEC is phosphorylated by cellular kinases, and that the complex pattern of NEC phosphorylation has functional relevance.
Journal ArticleDOI
Phenotypical Characterization of the Nuclear Egress of Recombinant Cytomegaloviruses Reveals Defective Replication upon ORF-UL50 Deletion but Not pUL50 Phosphosite Mutation.
Sigrun Häge,Eric Sonntag,Adriana Svrlanska,Eva Maria Borst,Anne-Charlotte Stilp,Deborah Horsch,Regina Müller,Barbara Kropff,Jens Milbradt,Thomas Stamminger,Ursula Schlötzer-Schrehardt,Manfred Marschall +11 more
TL;DR: In this paper, the pUL50-pUL53 core of the human cytomegalovirus (HCMV) is determined by the paulin-like pUL53 protrusion, which regulates multicomponent assembly with NEC-associated proteins and capsids.
Journal ArticleDOI
A Noncanonical Function of Polycomb Repressive Complexes Promotes Human Cytomegalovirus Lytic DNA Replication and Serves as a Novel Cellular Target for Antiviral Intervention.
Adriana Svrlanska,Anna Reichel,Eva-Maria Schilling,Myriam Scherer,Thomas Stamminger,Nina Reuter +5 more
TL;DR: An enzymatically independent, noncanonical function of both PRC1 and PRC2 during HCMV DNA replication is revealed, which may serve as a novel cellular target for antiviral therapy and observe that a subclass of inhibitory drugs that affect the abundance of PcG proteins strongly interferes with viral replication.
Journal ArticleDOI
The Autophagy-Initiating Protein Kinase ULK1 Phosphorylates Human Cytomegalovirus Tegument Protein pp28 and Regulates Efficient Virus Release.
TL;DR: The study provides evidence for a proviral role of several autophagy-related proteins suggesting that HCMV has developed strategies to usurp components of the autophagic machinery for its own benefit.
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Wedelolactone inhibits human cytomegalovirus replication by targeting distinct steps of the viral replication cycle.
TL;DR: WDL is identified as a potent agent against HCMV which interferes at two distinct steps of viral replication cycle, and the existence of additional mechanisms that impede viral IE expression is suggested.