Adviye A. Tolun

TL;DR: A digital microfluidic platform is presented a new technology for a newborn screening laboratory to screen LSDs by fully automating all the liquid-handling operations in an inexpensive system, providing rapid results.

TL;DR: Hepatitis C virus G3, but not G2, selectively interferes with the late cholesterol synthesis pathway, evidenced by lower distal sterol metabolites and preserved lanosterol levels, which may explain why hypocholesterolemia persists in chronic HCV infection, and is not overcome by host cholesterol compensatory mechanisms.

TL;DR: Results indicate that urinary F2-isoprostanes are valid biomarkers and allantoin is a promising biomarker of oxidative status in humans in response to treatments related either to generation of free radicals (chemotherapy and radiation therapy) or to antioxidants (inborn metabolic diseases and Down syndrome).

TL;DR: A rapid and specific assay for urinary allantoin is developed using ultra-performance liquid chromatography-tandem mass spectrometry suitable for high-throughput clinical studies and was accurate, precise, and sensitive.

TL;DR: A convenient single-step fluorometric microplate enzyme assay has been developed and validated for clinical diagnosis of MPS II using dried blood spots (DBS) and compared well with a recently reported digital microfluidic method.