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Affan A. Sher
Researcher at University of Manitoba
Publications - 6
Citations - 224
Affan A. Sher is an academic researcher from University of Manitoba. The author has contributed to research in topics: Autophagy & Zika virus. The author has an hindex of 4, co-authored 5 publications receiving 138 citations.
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Journal ArticleDOI
The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections
Parvaneh Mehrbod,Sudharsana R. Ande,Javad Alizadeh,Shahrzad Rahimizadeh,Aryana Shariati,Hadis Malek,Mohammad Hashemi,Kathleen K. M. Glover,Affan A. Sher,Kevin M. Coombs,Saeid Ghavami +10 more
TL;DR: This review article focuses upon how apoptosis, autophagy, and UPR are involved in the regulation of cellular responses to arboviruses, influenza virus and HIV infections.
Journal ArticleDOI
Zika Virus Infection Disrupts Astrocytic Proteins Involved in Synapse Control and Axon Guidance.
TL;DR: Almost 300 astrocyte proteins significantly dysregulated by ZIKV infection that span diverse functions and signaling pathways, including protein translation, synaptic control, cell migration and differentiation are identified.
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TAPP Adaptors Control B Cell Metabolism by Modulating the Phosphatidylinositol 3-Kinase Signaling Pathway: A Novel Regulatory Circuit Preventing Autoimmunity.
Nipun Jayachandran,Edgard M. Mejia,Kimia Sheikholeslami,Affan A. Sher,Sen Hou,Grant M. Hatch,Aaron J. Marshall +6 more
TL;DR: The findings show that TAPP–PI(3,4)P2 interaction controls activation of glycolysis and highlights the significance of this pathway for B cell activation, GC responses, and autoimmunity.
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Autophagy Modulators Profoundly Alter the Astrocyte Cellular Proteome
TL;DR: Analysis of U-251 astrocytic cell proteins after drug treatment with BafilomycinA1 and Rapamycin indicates that these two compounds, routinely used to help dissect cellular autophagy, have much more profound effects upon cellular proteins.
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Contribution of Thioredoxin1 in Modulation of Lysosomal Autophagy
TL;DR: The data indicate that Trx1 is important for maintaining lysosomal activity and perhaps acidification, in agreement with previous reports that link a healthy balance of Trx-TrxR to proper protein degradation system.