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Afisi S. Ismaila
Researcher at GlaxoSmithKline
Publications - 129
Citations - 5322
Afisi S. Ismaila is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: Medicine & COPD. The author has an hindex of 22, co-authored 85 publications receiving 4341 citations. Previous affiliations of Afisi S. Ismaila include McMaster University & Research Triangle Park.
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Journal ArticleDOI
A tutorial on pilot studies: the what, why and how
Lehana Thabane,Lehana Thabane,Jinhui Ma,Jinhui Ma,Rong Chu,Rong Chu,Ji Cheng,Ji Cheng,Afisi S. Ismaila,Afisi S. Ismaila,Lorena P. Rios,Lorena P. Rios,Reid Robson,Marroon Thabane,Lora Giangregorio,Charles H. Goldsmith,Charles H. Goldsmith +16 more
TL;DR: A detailed examination of the key aspects of pilot studies for phase III trials including the general reasons for conducting a pilot study, the relationships between pilot studies, proof-of-concept studies, and adaptive designs, and some suggestions on how to report the results of pilot investigations using the CONSORT format.
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Effectiveness of Cholinesterase Inhibitors and Memantine for Treating Dementia: Evidence Review for a Clinical Practice Guideline
Parminder Raina,Pasqualina Santaguida,Afisi S. Ismaila,Christopher Patterson,David Cowan,Mitchell Levine,Lynda Booker,Mark Oremus +7 more
TL;DR: This systematic review systematically evaluates the evidence for the effectiveness of these 5 drugs in improving outcomes in cognition, global function, behavior, and quality of life among patients with dementia.
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Conducting quantitative synthesis when comparing medical interventions: AHRQ and the Effective Health Care Program
Rongwei Fu,Gerald Gartlehner,Mark D Grant,Tatyana Shamliyan,Art Sedrakyan,Timothy J Wilt,Lauren Griffith,Mark Oremus,Parminder Raina,Afisi S. Ismaila,Pasqualina Santaguida,Joseph Lau,Thomas A Trikalinos +12 more
TL;DR: Recommendations for conducting quantitative synthesis, or meta-analysis, using study-level data in comparative effectiveness reviews (CERs) for the Evidence-based Practice Center (EPC) program of the Agency for Healthcare Research and Quality are established.
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AHRQ series paper 4: assessing harms when comparing medical interventions: AHRQ and the effective health-care program.
Roger Chou,Naomi Aronson,David C. Atkins,Afisi S. Ismaila,Pasqualina Santaguida,David H. Smith,Evelyn P Whitlock,Timothy J Wilt,David Moher +8 more
TL;DR: Advice for evaluating harms when conducting and reportingComparative effectiveness reviews is presented, including suggestions for prioritizing harms to be evaluated, use of terminology related to reporting of harms, selection of sources of evidence on harms, and assessment of risk of bias (quality) of harms reporting.
Journal ArticleDOI
Elevated Cardiac Troponin Measurements in Critically Ill Patients
Wendy Lim,Ismael Qushmaq,Philip J. Devereaux,Diane Heels-Ansdell,François Lauzier,Afisi S. Ismaila,Mark Crowther,Deborah J. Cook +7 more
TL;DR: Elevated cTn measurements among critically ill patients are associated with increased mortality and ICU length of stay and research is needed to clarify the underlying causes and examine their clinical significance.