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Afshin Mahmoudi
Researcher at Celgene
Publications - 5
Citations - 782
Afshin Mahmoudi is an academic researcher from Celgene. The author has contributed to research in topics: Pomalidomide & Cereblon. The author has an hindex of 5, co-authored 5 publications receiving 688 citations.
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Journal ArticleDOI
Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide.
Antonia Lopez-Girona,Derek Mendy,Takumi Ito,Karen Miller,Anita Gandhi,Jian Kang,Satoki Karasawa,Gilles Carmel,Pilgrim Jackson,Mahan Abbasian,Afshin Mahmoudi,Brian E. Cathers,Emily Rychak,Svetlana Gaidarova,Roger Shen-Chu Chen,Peter H. Schafer,Hiroshi Handa,Thomas O. Daniel,Jilly F. Evans,Rajesh Chopra +19 more
TL;DR: Biophysical, biochemical and gene silencing studies show that CRBN is a proximate, therapeutically important molecular target of lenalidomid and pomalidomide.
Journal ArticleDOI
Measuring cereblon as a biomarker of response or resistance to lenalidomide and pomalidomide requires use of standardized reagents and understanding of gene complexity.
Anita Gandhi,Derek Mendy,Michelle Waldman,Gengxin Chen,Emily Rychak,Karen Miller,Svetlana Gaidarova,Yan Ren,Maria Wang,Michael Breider,Gilles Carmel,Afshin Mahmoudi,Pilgrim Jackson,Mahan Abbasian,Brian E. Cathers,Peter H. Schafer,Thomas O. Daniel,Antonia Lopez-Girona,Anjan Thakurta,Rajesh Chopra +19 more
TL;DR: These studies characterized a cereblon monoclonal antibody CRBN65, with high sensitivity and specificity in Western analysis and immunohistochemistry that is superior to commercially available antibodies, and showed lack of correlation between Cereblon protein and mRNA levels.
Journal ArticleDOI
Protein Degradation via CRL4CRBN Ubiquitin Ligase: Discovery and Structure-Activity Relationships of Novel Glutarimide Analogs That Promote Degradation of Aiolos and/or GSPT1.
Joshua Hansen,Kevin Ronald Condroski,Correa Matthew D,George W. Muller,Hon-Wah Man,Alexander L. Ruchelman,Weihong Zhang,Fan Vocanson,Tim Crea,Wei Liu,Gang Lu,Frans Baculi,Laurie LeBrun,Afshin Mahmoudi,Gilles Carmel,Matt Hickman,Chin-Chun Lu +16 more
TL;DR: The structure-activity relationships for analogs of 3 are described with exploration of the structurally related dioxoisoindoline class, and selective protein degradation could be achieved between the two proteins of interest, GSPT1 and Aiolos.
Journal ArticleDOI
Crystal Structures of PRK1 in Complex with the Clinical Compounds Lestaurtinib and Tofacitinib Reveal Ligand Induced Conformational Changes.
Philip P Chamberlain,Silvia L. Delker,Barbra Pagarigan,Afshin Mahmoudi,Pilgrim Jackson,Mahan Abbasian,Jeff Muir,Neil Raheja,Brian E. Cathers +8 more
TL;DR: The crystal structure of PRK1 in apo form, and also in complex with a panel of literature inhibitors including the clinical candidates lestaurtinib and tofacitinib, as well as the staurosporine analog Ro-31-8220 are described.
Journal ArticleDOI
Direct Binding with Cereblon Mediates the Antiproliferative and Immunomodulatory Action of Lenalidomide and Pomalidomide
Antonia Lopez-Girona,Derek Mendy,Karen Miller,Anita Gandhi,Jian Kang,Gilles Carmel,Mahan Abbasian,Afshin Mahmoudi,Pilgrim Jackson,Brian E. Cathers,Emily Rychak,Normand Richard,Helen Brady,Peter H. Schafer,Jilly F. Evans,Thomas O. Daniel,Rajesh Chopra +16 more
TL;DR: The results indicate that some of the immunomodulatory effects of lenalidomide and pomalidomides are mediated via CRBN, which is important for tumor surveillance by activated T cells.