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Afzal A. Siddiqui
Researcher at Texas Tech University Health Sciences Center
Publications - 65
Citations - 2354
Afzal A. Siddiqui is an academic researcher from Texas Tech University Health Sciences Center. The author has contributed to research in topics: Schistosoma mansoni & Schistosomiasis vaccine. The author has an hindex of 26, co-authored 65 publications receiving 2170 citations. Previous affiliations of Afzal A. Siddiqui include East Tennessee State University James H. Quillen College of Medicine & East Tennessee State University.
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Journal ArticleDOI
Diagnosis of Strongyloides stercoralis Infection
Afzal A. Siddiqui,Steven L. Berk +1 more
TL;DR: The clinical manifestations of strongyloidiasis are described as well as various diagnostic tests and treatment strategies, and several immunodiagnostic assays have been found ineffective in detecting disseminated infections and show extensive cross-reactivity with hookworms, filariae, and schistosomes.
Journal ArticleDOI
Characterization of Ca2+-dependent neutral protease (calpain) from human blood flukes, Schistosoma mansoni
Afzal A. Siddiqui,You Zhou,Ron B. Podesta,Steve R. Karcz,Cristina E. Tognon,Gil H. Strejan,Gregory A. Dekaban,Gregory A. Dekaban,Michael W. Clarke,Michael W. Clarke +9 more
TL;DR: Calcium-dependent, neutral cysteine-proteases (calpain) were purified from human blood flukes, Schistosoma mansoni and showed to function as a mediator of the surface membrane synthetic process.
Journal ArticleDOI
Enhancement of Sm-p80 (large subunit of calpain) induced protective immunity against Schistosoma mansoni through co-delivery of interleukin-2 and interleukin-12 in a DNA vaccine formulation.
Afzal A. Siddiqui,Troy Phillips,Hugues Charest,Ron B. Podesta,Martha L. Quinlin,Justin R. Pinkston,Jenny D. Lloyd,Janet Pompa,Rachael M. Villalovos,Michelle Paz +9 more
TL;DR: DNA immunization protocols using Sm-p80 with plasmids encoding interleukin-2 (IL-2) and IL-12 and co-injection of plasmid DNA encoding IL- 12 with Sm- p80 DNA yielded a protection level significantly greater than when only the Sm-P80 was used, which reinforces the potential of Sm-n80 as an excellent candidate for a schistosomiasis vaccine.
Journal ArticleDOI
Preclinical Prophylactic Efficacy Testing of Sm-p80–Based Vaccine in a Nonhuman Primate Model of Schistosoma mansoni Infection and Immunoglobulin G and E Responses to Sm-p80 in Human Serum Samples From an Area Where Schistosomiasis Is Endemic
Gul Ahmad,Weidong Zhang,Workineh Torben,Afzal Ahrorov,Raymond T. Damian,Roman F. Wolf,Gary L. White,David W. Carey,Pauline N. M. Mwinzi,Lisa Ganley-Leal,Ronald C. Kennedy,Afzal A. Siddiqui +11 more
TL;DR: The proof of concept to move Sm-p80 forward into further preclinical development leading to human clinical trials is provided, thus minimizing the risk of hypersensitivity reaction following vaccination with Sm- p80 in humans.
Journal ArticleDOI
Interferon-alpha upregulates gene expression of aquaporin-5 in human parotid glands.
John Kelly Smith,Afzal A. Siddiqui,L A Modica,Rhesa Dykes,C Simmons,J Schmidt,Guha A. Krishnaswamy,Steven L. Berk +7 more
TL;DR: The hypothesis that orally administered human interferon-alpha (HuIFN-alpha) benefits persons with xerostomia by augmenting the production of AQP5 protein by parotid gland epithelium is tested and it is concluded that IFN- alpha upregulates AQP 5 gene expression in human parotids acinar cells in vitro.