Hugues Charest

TL;DR: The capacity of splenic DC but not MΦ to synthesize de novo high levels of IL-12 within hours of exposure to microbial products in vivo, as well as the ability of the same stimuli to induce migration of DC to the T cell areas, argues that DC function simultaneously as both antigen-presenting cells and IL- 12 producing accessory cells in the initiation of cell-mediated immunity to intracellular pathogens.

TL;DR: Early infection accounts for approximately half of onward transmissions in this urban North American study, suggesting therapy at early stages of disease may prevent onward HIV transmission.

TL;DR: In this article, a population-based phylogenetic approach was used to characterize human immunodeficiency virus (HIV)-transmission dynamics in Quebec, where early infection accounts for approximately half of onward transmissions in this urban North American study.

TL;DR: Detailed genotypic and phenotypic characterization shows that low VE was instead related to mutations in the egg-adapted H3N2 vaccine strain rather than antigenic drift in circulating viruses, underscore the need to monitor vaccine viruses as well as circulating strains to explain vaccine performance.

TL;DR: Prior receipt of 2008-09 TIV was associated with increased risk of medically attended pH1N1 illness during the spring-summer 2009 in Canada and possible biological mechanisms and immunoepidemiologic implications are considered.