A
Agape M. Awad
Researcher at University of California, Los Angeles
Publications - 8
Citations - 350
Agape M. Awad is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Coenzyme Q – cytochrome c reductase & Polyunsaturated fatty acid. The author has an hindex of 6, co-authored 8 publications receiving 272 citations.
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Journal ArticleDOI
Small Amounts of Isotope-reinforced Polyunsaturated Fatty Acids Suppress Lipid Autoxidation
Shauna Hill,Connor R. Lamberson,Libin Xu,Randy To,Hui S. Tsui,Vadim V. Shmanai,Andrei V. Bekish,Agape M. Awad,Beth N. Marbois,Charles R. Cantor,Ned A. Porter,Catherine F. Clarke,Mikhail S. Shchepinov +12 more
TL;DR: It is shown that inclusion of only a small fraction of PUFAs deuterated at the bis-allylic sites is sufficient to profoundly inhibit the chain reaction of nondeuteratedPUFAs in yeast.
Journal ArticleDOI
Coenzyme Q10 deficiencies: pathways in yeast and humans.
Agape M. Awad,Michelle C. Bradley,Lucía Fernández-del-Río,Anish Nag,Hui S. Tsui,Catherine F. Clarke +5 more
TL;DR: Yeast provides a simple yet effective model to investigate and define the function and possible pathology of human COQ (yeast or human gene involved in CoQ biosynthesis) gene polymorphisms and mutations.
Journal ArticleDOI
Identification of Coq11, a New Coenzyme Q Biosynthetic Protein in the CoQ-Synthome in Saccharomyces cerevisiae
Christopher M. Allan,Agape M. Awad,Jarrett S. Johnson,Dyna I. Shirasaki,Charles Wang,Crysten E. Blaby-Haas,Sabeeha S. Merchant,Joseph A. Loo,Catherine F. Clarke +8 more
TL;DR: Discovery and characterization of yeast Coq biosynthetic proteins leads to an improved understanding of coenzyme Q biosynthesis and regulation and it is proposed that the open reading frame YLR290C be designated COQ11.
Journal ArticleDOI
Treatment with 2,4-Dihydroxybenzoic Acid Prevents FSGS Progression and Renal Fibrosis in Podocyte-Specific Coq6 Knockout Mice
Eugen Widmeier,Eugen Widmeier,Merlin Airik,Hannah Hugo,David Schapiro,Johannes Wedel,Chandra C. Ghosh,Makiko Nakayama,Ronen Schneider,Agape M. Awad,Anish Nag,Jang Cho,Markus Schueler,Catherine F. Clarke,Rannar Airik,Friedhelm Hildebrandt +15 more
TL;DR: These findings reveal a potential novel treatment strategy for those cases of human nephrotic syndrome that are caused by a primary dysfunction in the CoQ10 biosynthesis pathway.
Journal ArticleDOI
Kaempferol increases levels of coenzyme Q in kidney cells and serves as a biosynthetic ring precursor.
Lucía Fernández-del-Río,Anish Nag,Elena Gutiérrez Casado,Julia Ariza,Agape M. Awad,Akil I. Joseph,Ohyun Kwon,Eric Verdin,Rafael de Cabo,Claus Schneider,Jorge Z. Torres,M. I. Burón,Catherine F. Clarke,José M. Villalba +13 more
TL;DR: The role of kaempferol as a precursor that increases coenzyme Q levels, combined with its ability to upregulate Sirt3, is identified as a potential candidate in the design of interventions aimed on increasing endogenous Q biosynthesis, particularly in kidney.