Michelle C. Bradley

TL;DR: Yeast provides a simple yet effective model to investigate and define the function and possible pathology of human COQ (yeast or human gene involved in CoQ biosynthesis) gene polymorphisms and mutations.

TL;DR: The involvement of the ER-mitochondria contact site in regulation of CoQ6 biogenesis highlights an additional level of communication between these two organelles, and it is suggested that these outcomes contribute to the reduced respiration observed in ERMES mutants.

TL;DR: It is shown that expression of either human ortholog, COQ10A orCOQ10B, rescues yeast coq10Δ mutant phenotypes, restoring the function of respiratory-dependent growth on a nonfermentable carbon source and sensitivity to oxidative stress induced by treatment with PUFAs, which indicate a strong functional conservation of Coq10 across different organisms.

TL;DR: A previously unknown role for the chromatin remodeler SWI/SNF complex in the transition of yeast cells from fermentative to respiratory modes of metabolism is reported and a link between Snf2 expression and the splicing of PTC7 is uncovered.

TL;DR: It is demonstrated that RquA converts ubiquinone to RQ directly, the first in vivo synthetic production of RQ in Escherichia coli and Saccharomyces cerevisiae, two organisms that do not natively produce RQ.