Aggrey Dhabangi

TL;DR: Among children with lactic acidosis due to severe anemia, transfusion of longer-storage compared with shorter-storage RBC units did not result in inferior reduction of elevated blood lactate levels, and these findings have relevance regarding the efficacy of stored RBC transfusion for patients with critical tissue hypoxia and lactic acids due to anemia.

TL;DR: Results suggest the utility of combinatorial biomarker strategies as prognostic tests for severe malaria and generated simple biomarker combinations that accurately predicted death in an African pediatric population.

TL;DR: Dysregulation of the S1P pathway in the pathogenesis of human and murine CM is implicate and a novel therapeutic strategy to improve clinical outcome in severe malaria is suggested.

TL;DR: Qualitative data examining HIV serostatus and treatment disclosure practices and concerns of young people living with HIV in Uganda and the extent to which they are satisfied with current norms around HIV serstatus andreatment disclosure are presented are presented.

TL;DR: It is demonstrated that C5a is dysregulated in human CM and contributes to the pathogenesis of ECM via C5 aR-dependent inflammation and endothelial dysfunction.