https://rua.ua.es/dspace/bitstream/10045/57890/5/2015_Barbosa_etal_BiotechAdv_preprint.pdf

Strategies for the one-step immobilization–purification of enzymes as industrial biocatalysts

Immobilization of lipases on hydrophobic supports: immobilization mechanism, advantages, problems, and solutions.

https://pubs.rsc.org/en/content/articlepdf/2019/CY/C9CY00415G

Novozym 435: the “perfect” lipase immobilized biocatalyst?

Multicomponent synthesis of pyrano[2,3-d]pyrimidine derivatives via a direct one-pot strategy executed by novel designed copperated Fe3O4@polyvinyl alcohol magnetic nanoparticles

2,3-Dihydroquinazolin-4-one (DHQ) belongs to the class of nitrogen-containing heterocyclic compounds representing a core structural component in various biologically active compounds. In the past decades, several methodologies have been developed for the synthesis of the DHQ framework, especially the 2-substituted derivatives. Unfortunately, multistep syntheses, harsh reaction conditions, and the use of toxic reagents and solvents have limited their full potential as a versatile fragment. Recently, use of green chemistry and alternative strategies are being explored to prepare diverse DHQ derivatives. This fragment is used as a synthon for the preparation of biologically active quinazolinones and as a functional substrate for the synthesis of modified DHQ derivatives exhibiting different biological properties. In this review, we provide a comprehensive assessment of the synthesis and biological evaluations of DHQ derivatives.

/pdf/2-3-dihydroquinazolin-4-1h-one-as-a-privileged-scaffold-in-42p4nzt0gm.pdf

2,3-Dihydroquinazolin-4(1H)-one as a privileged scaffold in drug design

http://real.mtak.hu/7271/1/Process%20Biochemistry_2013-F.pdf

Hydrophobic adsorption and covalent immobilization of Candida antarctica lipase B on mixed-function-grafted silica gel supports for continuous-flow biotransformations

A series of 2,3-dihydroquinazolin-4(1H)-ones have been synthesized with good to excellent yields by one-pot reaction using isatoic anhydride, aldehydes, and ammonium acetate or amines in acetonitrile in the presence of 4 A molecular sieve modified with lanthanum(III) as an efficient heterogeneous catalyst. The catalyst could be reused without evident loss of activity.

One-Pot Three-Component Synthesis of 2,3-Dihydroquinazolin-4(1H)-Ones in the Presence of a Molecular Sieve Supported Lanthanum Catalyst

A series of 2,4,5-trisubstituted-imidazoles has been synthesized with good to excellent yields by the one-pot condensation reaction of 1,2-dicarbonyl compounds, benzaldehydes, and ammonium acetate in the presence of 4 A molecular sieves modified with titanium(IV) as an efficient heterogeneous catalyst. The catalyst could be recovered easily and reused without significant loss of activity.

One-Pot Three-Component Synthesis of 2,4,5-Triaryl-1H-imidazoles in the Presence of a Molecular Sieve Supported Titanium Catalyst under Mild Basic Conditions

Copper(II) on 4-A molecular sieves is an efficient catalyst for the preparation of imines from benzylamines under simple reaction conditions. No oxidative atmosphere or oxidizing agents are required. Preparative experiments showed that no aldehyde intermediate can be detected even under ambient atmospheric conditions.

Heterogeneous copper-catalyzed coupling of amines: a possible way for the preparation of imines

Transition-metal-catalyzed cross-coupling of organo­halides, ethers, sulfides, amines, and alcohols (and derivatives thereof) with Grignard reagents, known as the Kumada–Tamao–Corriu reaction, can be used to prepare important intermediates in the synthesis of numerous­ biologically active compounds. The most frequently used transition metals are nickel, palladium, and iron, but there are several examples for cross-coupling reactions catalyzed by copper, cobalt, manganese, chromium, etc. salts and complexes. The aim of this review is to summarize the most important transition-metal-catalyzed cross-coupling reactions realized in the period 2000 to 2020. 1 	Introduction 2 	Nickel Catalysis 3 	Palladium Catalysis 4 	Iron Catalysis 5 	Catalysis by Other Transition Metals 5.1 	Cobalt Catalysis 5.2 	Copper Catalysis 5.3 	Manganese Catalysis 5.4 	Chromium Catalysis 6 	Conclusion

Ágnes Magyar

Papers

Hydrophobic adsorption and covalent immobilization of Candida antarctica lipase B on mixed-function-grafted silica gel supports for continuous-flow biotransformations

One-Pot Three-Component Synthesis of 2,3-Dihydroquinazolin-4(1H)-Ones in the Presence of a Molecular Sieve Supported Lanthanum Catalyst

One-Pot Three-Component Synthesis of 2,4,5-Triaryl-1H-imidazoles in the Presence of a Molecular Sieve Supported Titanium Catalyst under Mild Basic Conditions

Heterogeneous copper-catalyzed coupling of amines: a possible way for the preparation of imines

Transition-Metal-Catalyzed Cross-Coupling Reactions of Grignard Reagents