Agnieszka Rybak

TL;DR: It is demonstrated that the pluripotency factor Lin-28 binds the pre-let-7 RNA and inhibits processing by the Dicer ribonuclease in ES and EC cells, suggesting that let-7, mir-125 and lin-28 participate in an autoregulatory circuit that controls miRNA processing during NS-cell commitment.

TL;DR: Comparison of primary, precursor, and mature let‐7 RNA levels during both embryonic brain development and neural differentiation of embryonic stem cells and embryocarcinoma (EC) cells suggest post‐transcriptional regulation ofLet‐7 accumulation.

TL;DR: In this article, an additional let-7 target, mLin41 (mouse homologue of lin-41), was investigated as a potential contributor to the regulatory circuit controlling pluripotency.

TL;DR: Trim-NHL proteins are defined by RING, B-Box and Coiled-coil protein motifs (referred to collectively as the Trim domain) coupled to an NHL domain, which is a scaffold for the assembly of a translational repressor complex by the Brat proto-oncogene, a wellstudied family member in Drosophila as discussed by the authors.

TL;DR: It is reported that ssRNA causes neurodegeneration and neuroinflammation dependent on TLR7 in the CNS and a possible mechanism through which extracellularly delivered ssRNA contributes to CNS damage is pointed to, which would determine an obligatory role for TLR 7 in this pathway.