A
Agustina Cabral
Researcher at National Scientific and Technical Research Council
Publications - 22
Citations - 1003
Agustina Cabral is an academic researcher from National Scientific and Technical Research Council. The author has contributed to research in topics: Ghrelin & Growth hormone secretagogue receptor. The author has an hindex of 17, co-authored 20 publications receiving 751 citations. Previous affiliations of Agustina Cabral include National University of La Plata.
Papers
More filters
Journal ArticleDOI
Ghrelin indirectly activates hypophysiotropic CRF neurons in rodents.
TL;DR: The mechanism by which ghrelin activates hypophysiotropic CRF neurons in mice is characterized, finding that peripheral or intra-cerebro-ventricular administration ofghrelin strongly activates c-fos – a marker of cellular activation – in CRF-producing neurons and activates CRF gene expression in the paraventricular nucleus of the hypothalamus.
Journal ArticleDOI
N-Terminal Liver-Expressed Antimicrobial Peptide 2 (LEAP2) Region Exhibits Inverse Agonist Activity toward the Ghrelin Receptor.
Céline M'Kadmi,Agustina Cabral,Franco Barrile,Julien Giribaldi,Sonia Cantel,Marjorie Damian,Sophie Mary,Séverine Denoyelle,Sébastien Dutertre,Sylvie Péraldi-Roux,Jérémie Neasta,Catherine Oiry,Jean-Louis Banères,Jacky Marie,Mario Perello,Jean-Alain Fehrentz +15 more
TL;DR: It is found that both LEAP2 and its N-terminal part behave as inverse agonists of GHSR and as competitive antagonists of ghrelin-induced inositol phosphate production and calcium mobilization.
Journal ArticleDOI
Is Ghrelin Synthesized in the Central Nervous System
TL;DR: It is concluded that no irrefutable and reproducible evidence exists supporting the notion that ghrelin is synthetized, at physiologically relevant levels, in the central nervous system of adult mammals.
Journal ArticleDOI
Des‐acyl Ghrelin directly targets the arcuate nucleus in a ghrelin‐receptor independent manner and impairs the orexigenic effect of ghrelin
Gimena Fernandez,Agustina Cabral,María Paula Cornejo,P. N. De Francesco,G. Garcia-Romero,Mirta Reynaldo,Mario Perello +6 more
TL;DR: DAG specifically binds to and acts on a subset of arcuate nucleus (ARC) cells in a GHSR‐independent manner, and directly targets ARC neurones and antagonises the orexigenic effects of peripherally administered ghrelin.
Journal ArticleDOI
Divergent Neuronal Circuitries Underlying Acute Orexigenic Effects of Peripheral or Central Ghrelin: Critical Role of Brain Accessibility
TL;DR: The present study aimed to clarify which ghrelin brain targets participate in the short‐term orexigenic actions of gh Relin, and confirmed that peripherally administered Ghrelin dose‐dependently increases food intake and mainly activates c‐Fos in ARC neurones.