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Ahalya Selvaraj
Researcher at Columbia University
Publications - 4
Citations - 768
Ahalya Selvaraj is an academic researcher from Columbia University. The author has contributed to research in topics: Serum response factor & RHOA. The author has an hindex of 4, co-authored 4 publications receiving 733 citations.
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Journal ArticleDOI
Megakaryoblastic Leukemia 1, a Potent Transcriptional Coactivator for Serum Response Factor (SRF), Is Required for Serum Induction of SRF Target Genes
Bo Cen,Ahalya Selvaraj,Rebecca C. Burgess,Johann Hitzler,Zhigui Ma,Stephan W. Morris,Stephan W. Morris,Ron Prywes +7 more
TL;DR: The RBM15-MKL1 fusion protein formed by the t(1;22) translocation of acute megakaryoblastic leukemia had a markedly increased ability to activate SRE reporter genes, suggesting that its activation of SRF target genes may contribute to leukemogenesis.
Journal ArticleDOI
Myocardin/MKL family of SRF coactivators: key regulators of immediate early and muscle specific gene expression.
TL;DR: The regulation of this coactivator family is key to understanding how SRF target genes are activated during muscle cell differentiation or growth factor induced cell proliferation.
Journal ArticleDOI
Expression profiling of serum inducible genes identifies a subset of SRF target genes that are MKL dependent
Ahalya Selvaraj,Ron Prywes +1 more
TL;DR: It is suggested that a subset of immediate early and SRF target genes are activated by the Rho-MKL pathway, possibly due to other activation mechanisms such as MAPK phosphorylation of TCFs.
Journal ArticleDOI
Megakaryoblastic leukemia-1/2, a transcriptional co-activator of serum response factor, is required for skeletal myogenic differentiation.
Ahalya Selvaraj,Ron Prywes +1 more
TL;DR: The cloning of the third member of the myocardin/MKL family in humans, MKL2 is reported, which binds to and activates SRF similar tomyocardin and MKL1 and shows that the MKL family of proteins is required for skeletal myogenic differentiation.