Aidan J. O’Donnell

TL;DR: It is demonstrated that perturbation of parasite rhythms results in a twofold cost to the production of replicating and transmission stages, revealing a role for circadian rhythms in the evolution of host–parasite interactions.

TL;DR: This work focuses on mosquitoes, malaria parasites and vertebrate hosts, because this system offers the opportunity to integrate from genetic and molecular mechanisms to population dynamics and because disrupting rhythms offers a novel avenue for disease control.

TL;DR: How hosts use rhythms to defend against infection, why parasites have rhythms and whether parasites can manipulate host clocks to their own ends are explored and an interdisciplinary effort to drive this emerging field forward is proposed.

TL;DR: The study at the intersection of disease ecology and chronobiology opens up a new arena for studying host-parasite-vector coevolution and has broad implications for applied bioscience.

TL;DR: Serpentine receptor 10 (SR10) plays a role in regulating the schedule of the IDC in line with the timing of host daily rhythms, and multiple processes including DNA replication, and the ubiquitin and proteasome pathways, are affected by loss of coordination with host rhythms and by disruption of SR10.