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Aikaterini A. Nella
Researcher at University of Nebraska Medical Center
Publications - 6
Citations - 601
Aikaterini A. Nella is an academic researcher from University of Nebraska Medical Center. The author has contributed to research in topics: Oxidative stress & Myopathy. The author has an hindex of 5, co-authored 6 publications receiving 520 citations. Previous affiliations of Aikaterini A. Nella include United States Department of Veterans Affairs.
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Journal ArticleDOI
The Myopathy of Peripheral Arterial Occlusive Disease: Part 1. Functional and Histomorphological Changes and Evidence for Mitochondrial Dysfunction:
Iraklis I. Pipinos,Andrew Judge,Joshua T. Selsby,Zhen Zhu,Stanley A. Swanson,Aikaterini A. Nella,Stephen L. Dodd +6 more
TL;DR: Evidence is provided that a state of repetitive cycles of exercise-induced ischemia followed by reperfusion at rest operates in PAD patients and mediates a large number of structural and metabolic changes in the muscle, resulting in reduced strength and function.
Journal ArticleDOI
The myopathy of peripheral arterial occlusive disease: Part 2. Oxidative stress, neuropathy, and shift in muscle fiber type.
Iraklis I. Pipinos,Andrew Judge,Joshua T. Selsby,Zhen Zhu,Stanley A. Swanson,Aikaterini A. Nella,Stephen L. Dodd +6 more
TL;DR: Accumulating evidence that oxidative stress related to ischemia reperfusion is probably the major operating mechanism of peripheral arterial occlusive disease myopathy is reviewed and important new findings of a possible neuropathy and a shift in muscle fiber type are reviewed.
Journal ArticleDOI
Oxidative damage and myofiber degeneration in the gastrocnemius of patients with peripheral arterial disease
Dustin J. Weiss,George P. Casale,Panagiotis Koutakis,Aikaterini A. Nella,Stanley A. Swanson,Zhen Zhu,Dimitrios Miserlis,Jason M. Johanning,Jason M. Johanning,Iraklis I. Pipinos,Iraklis I. Pipinos +10 more
TL;DR: This study developed and validated fluorescence microscopy procedures for quantitative analysis of carbonyl groups and 4-hydroxy-2-nonenal (HNE) adducts in myofibers of biopsy specimens from human gastrocnemius and establishes oxidative damage to myofiberers as a possible cause of PAD myopathy.
Journal ArticleDOI
Chronically ischemic mouse skeletal muscle exhibits myopathy in association with mitochondrial dysfunction and oxidative damage
Iraklis I. Pipinos,Stanley A. Swanson,Zhen Zhu,Aikaterini A. Nella,Dustin J. Weiss,Tanuja L. Gutti,Rodney D. McComb,B. Timothy Baxter,Thomas G. Lynch,George P. Casale +9 more
TL;DR: It is demonstrated for the first time that inflow arterial occlusion alone, i.e., in the absence of other comorbid conditions, causes myopathy with mitochondrial dysfunction and increased oxidative stress, recapitulating the muscle pathology of PAD patients.
Journal ArticleDOI
Mitochondriopathy of Peripheral Arterial Disease
Konstantinos I. Makris,Aikaterini A. Nella,Aikaterini A. Nella,Zhen Zhu,Zhen Zhu,Stanley A. Swanson,Stanley A. Swanson,George P. Casale,Tanuja L. Gutti,Tanuja L. Gutti,Andrew Judge,Iraklis I. Pipinos +11 more
TL;DR: This review presents the current histomorphologic, physiologic, and biochemical evidence defining the nature of this mitochondriopathy and discusses its contribution to the pathogenesis and clinical manifestations of PAD.