Aipm Anthal Smits

TL;DR: The main current challenges for in situ cardiovascular regeneration are pinpointed and further address, namely the achievement of tissue homeostasis, the development of predictive models for long-term performances of the implanted grafts, and the necessity for stratification for successful clinical translation.

TL;DR: This study proves that functional blood vessels can be formed in situ through the host inflammatory response, specifically by blood-borne cells, and proves the regenerative potential of cells in the circulatory system in the setting of in situ vascular tissue engineering.

TL;DR: Results showed that ECFCs do not behave like mature endothelial cells in a 3D fibrous environment.

TL;DR: Tissue engineered aortic valves can provide such an autologous, viable valve with the potential to grow, adapt, and regenerate within the hemodynamic environment, and apparently, the pediatric and young adult population would benefit most from such a engineered valve.

TL;DR: The development of mechanically stable grafts with non-cell adhesive properties via a mix-and-match approach using ureido-pyrimidinone (UPy)-modified supramolecular polymers is reported, providing the first steps toward advanced supramolescular biomaterials for in situ vascular tissue engineering with control over selective cell capturing.