V
Valentina Bonito
Researcher at Eindhoven University of Technology
Publications - 11
Citations - 386
Valentina Bonito is an academic researcher from Eindhoven University of Technology. The author has contributed to research in topics: Tissue engineering & Macrophage polarization. The author has an hindex of 8, co-authored 10 publications receiving 260 citations. Previous affiliations of Valentina Bonito include Philips.
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Journal ArticleDOI
Biomaterial-driven in situ cardiovascular tissue engineering : a multi-disciplinary perspective
TL;DR: The main current challenges for in situ cardiovascular regeneration are pinpointed and further address, namely the achievement of tissue homeostasis, the development of predictive models for long-term performances of the implanted grafts, and the necessity for stratification for successful clinical translation.
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Macrophage-Driven Biomaterial Degradation Depends on Scaffold Microarchitecture.
Tamar B Wissing,Valentina Bonito,Eline E. van Haaften,Marina van Doeselaar,Marieke Brugmans,Henk M. Janssen,Carlijn V. C. Bouten,Anthal I.P.M. Smits +7 more
TL;DR: Electrospun poly-ε-caprolactone-bisurea scaffolds with either 2 or 6 μm isotropic or anisotropic fibers were seeded with THP-1 derived human macrophages and cultured in vitro for 4 or 8 days, revealing that macroph age-induced oxidative degradation in particular was dependent on scaffold microarchitecture.
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Modulation of macrophage phenotype and protein secretion via heparin-IL-4 functionalized supramolecular elastomers.
Valentina Bonito,Anthal I.P.M. Smits,Olga J. G. M. Goor,Bastiaan D. Ippel,Anita Anita Driessen-Mol,T.J.A.G. Münker,Anton W. Bosman,Tristan Mes,Patricia Y. W. Dankers,Carlijn V. C. Bouten +9 more
TL;DR: It was demonstrated that the supramolecular IL-4-heparin functionalization effectively promoted macrophage polarization into an anti-inflammatory phenotype, in terms of morphology, immunohistochemistry and cytokine secretion.
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Influence of absorption induced thermal initiation pathway on irradiance threshold for laser induced breakdown.
Babu Varghese,Valentina Bonito,Martin Jurna,Jonathan Alambra Palero,Margaret Ruth Horton,Rieko Verhagen +5 more
TL;DR: Creating breakdown with lower irradiance threshold that is specific at the target chromophore can provide intrinsic target selectivity and improve safety and efficacy of skin treatment methods that use laser induced breakdown.
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Cyclic Strain Affects Macrophage Cytokine Secretion and Extracellular Matrix Turnover in Electrospun Scaffolds.
TL;DR: In situ tissue engineering (TE) is an approach, in which acellular resorb... as discussed by the authors, where macrophage behavior has become a high-potential target strategy for regenerative therapies.