A
Aitziber Portero
Researcher at University of the Basque Country
Publications - 7
Citations - 536
Aitziber Portero is an academic researcher from University of the Basque Country. The author has contributed to research in topics: Angiogenesis & Vascular endothelial growth factor. The author has an hindex of 5, co-authored 7 publications receiving 494 citations.
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Journal ArticleDOI
Cell microencapsulation technology: towards clinical application.
Ainhoa Murua,Aitziber Portero,Gorka Orive,Rosa Ma Hernández,María de Castro,José Luis Pedraz +5 more
TL;DR: The most important advantages of this type of "living" drug release strategy are highlighted, but also its limitations pointed out, and the major challenges to be addressed in the forthcoming years are described.
Journal ArticleDOI
The effect of encapsulated VEGF-secreting cells on brain amyloid load and behavioral impairment in a mouse model of Alzheimer’s disease
Carlos Spuch,Desiree Antequera,Aitziber Portero,Gorka Orive,Rosa Ma Hernández,José Antonio Molina,Félix Bermejo-Pareja,José Luis Pedraz,Eva Carro +8 more
TL;DR: Stereologically-implanted encapsulated VEGF-secreting cells could offer an alternative strategy in the treatment of AD and suggest a new potential therapeutic approach that could be developed for AD, to enhance Abeta clearance and neurovascular repair, and to protect the cognitive behavior.
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Delivery of immunostimulatory monoclonal antibodies by encapsulated hybridoma cells.
Juan Dubrot,Aitziber Portero,Gorka Orive,Rosa Maria Hernandez,Asis Palazon,Ana Rouzaut,Jose Luis Perez-Gracia,Sandra Hervas-Stubbs,José Luis Pedraz,Ignacio Melero +9 more
TL;DR: The antitumor therapeutic activity of the strategy was studied on established CT26 colon carcinomas resulting in complete tumor eradication in an elevated fraction of cases and strong tumor-specific CTL responses with either anti-CD137 or anti-OX40 producing hybridomas, thus offering proof of the concept.
Journal ArticleDOI
Encapsulated VEGF-secreting cells enhance proliferation of neuronal progenitors in the hippocampus of AβPP/Ps1 mice.
Desiree Antequera,Aitziber Portero,Marta Bolós,Gorka Orive,Rosa Maria Hernandez,José Luis Pedraz,Eva Carro +6 more
TL;DR: It is concluded that stereologically-implanted VEGF-microcapsules exert an acute and long-standing neurotrophic effects, and could be utilized to improve potential therapies to control the progression of AD.