Showing papers in "Journal of Controlled Release in 2008"

TL;DR: There is a highly promising role of stimuli-responsive nanocarrier systems for drug and gene delivery in the future with greater understanding of the difference between normal and pathological tissues and cells.

TL;DR: This review gives an account of the different drug delivery systems which make use of albumin as a drug carrier with a focus on those systems that have reached an advanced stage of preclinical evaluation or that have entered clinical trials.

TL;DR: These studies suggest that Pluronics have a broad spectrum of biological response modifying activities which make it one of the most potent drug targeting systems available, resulting in a remarkable impact on the emergent field of nanomedicine.

TL;DR: A link between nano-emulsion formulation methods and nanoparticle generation is proposed, while at the same time bearing in mind the above-mentioned parameters for active molecule encapsulation.

TL;DR: Important findings of the past decade on the encapsulation and release profiles of macromolecular therapeutics from PLGA and PLGA-based nano/microparticles are discussed critically in relation to nature and type of bioactive molecule, carrier polymer and experimental variables that influence the delivery of macrochemical therapeutics.

TL;DR: This review focuses on recent development of the preparation and application for drug delivery of the block copolymer hydrogels that respond to temperature, pH or both stimuli, including poly(N-substituted acrylamide)-based blockcopolymers, poloxamers and their derivatives, poly(ethylene glycol)-polyester block copolemers, polyelectrolyte-based blockCopolymers and the polyelectrodynamic-modified thermo-sensitive block

TL;DR: This review highlights recent progress of the pH-sensitive nanotechnology developed in Bae research group to overcome multidrug resistance of various tumors.

TL;DR: A global view of organogels is provided, with special emphasis on the interplay between the gelator's structural characteristics and the ensuing intermolecular interactions, for active agent administration via diverse routes such as transdermal, oral, and parenteral.

TL;DR: The earliest days when the "controlled drug delivery" (CDD) field began, the pioneers who launched this exciting and important field, and the key people who came after them are described, along with many historical anecdotes provided by the key pioneers and researchers in the field.

TL;DR: In this review emphasis is placed on processing techniques, microstructure, drug release profiles, biocompatibility and other relevant aspects necessary for advancing the therapeutic field of antibiotic-eluting devices.

TL;DR: The barriers to CNS drug delivery, strategies to bypass the blood-brain barrier and characterization methods of SLNs and their usefulness are discussed.

TL;DR: Remote controlled pulsatile drug release was characterized for different drugs as well as for different ON-OFF durations of the AMF.

TL;DR: The recent results obtained with two classes of degradable gene delivery systems, namely those based on water-soluble cationic polymers and on micro- and nanoparticles will be summarized and discussed.

TL;DR: The delivery of CPT to tumor tissues at a high concentration, with the assistance of HGC nanoparticles, exerted a potent therapeutic effect and reveal the promising potential of H GC nanoparticles-encapsulated CPT as a stable and effective drug delivery system in cancer therapy.

TL;DR: This approach may replace the need for cell-specific antibodies or targeting ligands, thereby providing a general strategy for solid tumor targeting and increasing DOX potency in various wild and multidrug resistant (MDR) cell lines.

TL;DR: The feasibility of using PEC micelles as a potential carrier for therapeutic siRNAs in local and systemic treatment of cancer is demonstrated.

TL;DR: The most important advantages of this type of "living" drug release strategy are highlighted, but also its limitations pointed out, and the major challenges to be addressed in the forthcoming years are described.

TL;DR: The present results indicate that HGC nanoparticles are a promising carrier for the anticancer drug CDDP, as shown by changes in tumor volumes, body weights, and survival rates, as well as by immunohistological TUNEL assay data.

TL;DR: An overview on the current state of the art of the use of polymer blends as coating materials for controlled drug delivery, explaining the major advantages and potential pitfalls and special emphasis is laid on the underlying drug release mechanisms.

TL;DR: The dynamic in vitro lipolysis model seems to provide highly useful initial guidelines in the development process of oral lipid based drug delivery systems for poorly water soluble drugs, and it predicts phenomena that occur in the pre-enterocyte stages of the intestinal absorption cascade.

TL;DR: This review focuses on the current use of injectable in situ chitosan hydrogels in cancer treatment and their cytotoxic properties, loading and in vitro release of drugs, their effect on cell growth in vitro and inhibition of tumor growth in vivo using mouse models.

TL;DR: Two poly(lactic-co-glycolic acid) microsphere formulations, with different polymer molecular weights were investigated to determine whether an in vitro and in vivo relationship could be established for dexamethasone release and a linear in vitro-in vivo relationship was established.

TL;DR: The fabrication of drug-loaded silk fibroin (SF) spheres under very mild processing conditions using the laminar jet break-up of an aqueous SF solution, which was induced by a nozzle vibrating at controlled frequency and amplitude, resulted in high encapsulation efficiencies.

TL;DR: The targeted LPH-NP (PEGylated with ligand) silenced 80% of luciferase activity in the metastatic B16F10 tumor in the lung after a single i.v. injection.

TL;DR: Under optimal conditions for cancer therapy, the DTX-HGC nanoparticles showed higher antitumor efficacy such as reduced tumor volume and increased survival rate in A549 lung cancer cells- bearing mice and strongly reduced the anticancer drug toxicity compared to that of free DTX in tumor-bearing mice.

TL;DR: The results indicated that OX26(34)-PO is a promising carrier for peptide brain delivery and improved the scopolamine-induced learning and memory impairments in a water maze task via i.v. administration.

TL;DR: Targeted addressing of two major subcellular compartments by simply controlling the particle morphology/size could find a number of applications in cellular biomedicine.

TL;DR: A number of in vivo and in vitro experiments demonstrating that that the oral administration of the cytotoxics formulated with the Pluronic-PAA copolymer micelles results in enhanced drug bioavailability are reviewed.

TL;DR: PEGylation led to improved colloidal stability of polyplexes and significantly increased cellular uptake and transfection efficiency in NIH/3T3, L929 and MeWo cells compared to trimethyl chitosan, highlighting the importance of investigating polyplex stability under different pH- and ionic strength conditions.

TL;DR: This field of research is promising as a possible alternative to other approaches for diabetes treatment, and recent developments made represent significant progress in terms of biocompatibility, selectivity, pharmacokinetics, and easiness of administration.