A
Ajay Kumar
Researcher at Council of Scientific and Industrial Research
Publications - 69
Citations - 2011
Ajay Kumar is an academic researcher from Council of Scientific and Industrial Research. The author has contributed to research in topics: Apoptosis & Programmed cell death. The author has an hindex of 23, co-authored 68 publications receiving 1665 citations. Previous affiliations of Ajay Kumar include University of Jammu & Academy of Scientific and Innovative Research.
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Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic cell death of human myeloid leukemia HL-60 cells by a dietary compound withaferin A with concomitant protection by N-acetyl cysteine.
Fayaz Malik,Ajay Kumar,Shashi Bhushan,Sheema Khan,Aruna Bhatia,Krishan Avtar Suri,Ghulam Nabi Qazi,Jaswant Singh +7 more
TL;DR: The results of these studies demonstrate that withaferinA induced early ROS generation and mitochondrial dysfunction in cancer cells trigger events responsible for mitochondrial -dependent and -independent apoptosis pathways.
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A triterpenediol from Boswellia serrata induces apoptosis through both the intrinsic and extrinsic apoptotic pathways in human leukemia HL-60 cells
Shashi Bhushan,Ajay Kumar,Fayaz Malik,Samar S. Andotra,Vijay Kumar Sethi,Indu Pal Kaur,Subhash C. Taneja,Ghulam Nabi Qazi,Jaswant Singh +8 more
TL;DR: It is demonstrated that TPD produces oxidative stress in cancer cells that triggers self-demise by ROS and NO regulated activation of both the intrinsic and extrinsic signaling cascades.
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An essential oil and its major constituent isointermedeol induce apoptosis by increased expression of mitochondrial cytochrome c and apical death receptors in human leukaemia HL-60 cells.
Ajay Kumar,Fayaz Malik,Shashi Bhushan,Vijay Kumar Sethi,Ashok Kumar Shahi,Jagdeep Kaur,Subhash C. Taneja,Ghulam Nabi Qazi,Jaswant Singh +8 more
TL;DR: An essential oil from a lemon grass variety of Cymbopogon flexuosus and its major chemical constituent sesquiterpene isointermedeol were investigated for their ability to induce apoptosis in human leukaemia HL-60 cells and appeared to follow similar signaling apoptosis pathways.
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Alborixin clears amyloid-β by inducing autophagy through PTEN-mediated inhibition of the AKT pathway.
Abubakar Wani,Mehak Gupta,Masroor Ahmad,Aabid Manzoor Shah,Aitizaz Ul Ahsan,Parvaiz H. Qazi,Fayaz Malik,Gurdarshan Singh,Parduman R. Sharma,Amal Kaddoumi,Sandip B. Bharate,Ram A. Vishwakarma,Ajay Kumar +12 more
TL;DR: It is found that autophagy induced by alborixin substantially cleared Aβ in microglia and primary neuronal cells and led to significant reduction of Aβ-mediated cytotoxicity in primary neurons and differentiated N2a cells.
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Autophagy triggered by magnolol derivative negatively regulates angiogenesis
TL;DR: The robust autophagy triggered by Ery5, inhibited angiogenesis and caused cell death independent of the apoptosis in human umbilical cord vein endothelial cells and PC-3 cells.