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Akihiro Asakawa
Researcher at Kobe University
Publications - 67
Citations - 6250
Akihiro Asakawa is an academic researcher from Kobe University. The author has contributed to research in topics: Gastric emptying & Ghrelin. The author has an hindex of 29, co-authored 62 publications receiving 6044 citations. Previous affiliations of Akihiro Asakawa include Kyoto University & Shiga University of Medical Science.
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Journal ArticleDOI
Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin.
Akihiro Asakawa,Akio Inui,Toshihiro Kaga,Hideki Yuzuriha,Toshiaki Nagata,Naohiko Ueno,Susumu Makino,Mineko Fujimiya,Akira Niijima,Masayuki A. Fujino,Masato Kasuga +10 more
TL;DR: Ghrelin, which is negatively regulated by leptin and IL-1 beta, is secreted by the stomach and increases arcuate NPY expression, which in turn acts through Y(1) receptors to increase food intake and decrease energy expenditure.
Journal ArticleDOI
Antagonism of ghrelin receptor reduces food intake and body weight gain in mice.
Akihiro Asakawa,Akio Inui,Toshihiro Kaga,Goro Katsuura,Mineko Fujimiya,Masayuki A. Fujino,Masato Kasuga +6 more
TL;DR: Gastric peptide ghrelin and GHS-R may be promising therapeutic targets not only for anorexia-cachexia but also for obesity and type 2 diabetes, which are becoming increasingly prevalent worldwide.
Journal ArticleDOI
Stomach regulates energy balance via acylated ghrelin and desacyl ghrelin
Akihiro Asakawa,Akio Inui,Mineko Fujimiya,Ruka Sakamaki,Naotaka Shinfuku,Y Ueta,Michael M. Meguid,Masato Kasuga +7 more
TL;DR: Findings indicate that in contrast to acylated ghrelin, desacyl gh Relin induces a negative energy balance by decreasing food intake and delaying gastric emptying.
Journal ArticleDOI
Ghrelin, appetite, and gastric motility: the emerging role of the stomach as an endocrine organ
Akio Inui,Akihiro Asakawa,Cyril Y. Bowers,Giovanni Mantovani,Alessandro Laviano,Michael M. Meguid,Mineko Fujimiya +6 more
TL;DR: The novel stomach hormone ghrelin, which is an endogenous agonist at the growth hormone secretagogne receptor and is the motilin‐related family of regulatory peptides, stimulates appetite and induces a positive energy balance leading to body weight gain.
Journal ArticleDOI
Characterization of the effects of pancreatic polypeptide in the regulation of energy balance.
Akihiro Asakawa,Akio Inui,Hideki Yuzuriha,Naohiko Ueno,Goro Katsuura,Mineko Fujimiya,Masayuki A. Fujino,Akira Niijima,Michael M. Meguid,Michael M. Meguid,Masato Kasuga +10 more
TL;DR: Observations indicate that PP may influence food intake, energy metabolism, and the expression of hypothalamic peptides and gastric ghrelin.