A
Akihiro Furusaka
Researcher at Jikei University School of Medicine
Publications - 14
Citations - 1145
Akihiro Furusaka is an academic researcher from Jikei University School of Medicine. The author has contributed to research in topics: Hepatitis C virus & Insulin receptor. The author has an hindex of 10, co-authored 14 publications receiving 1118 citations. Previous affiliations of Akihiro Furusaka include Tokyo Medical University.
Papers
More filters
Journal ArticleDOI
Efficient replication of the genotype 2a hepatitis C virus subgenomic replicon
Takanobu Kato,Tomoko Date,Michiko Miyamoto,Akihiro Furusaka,Katsutoshi Tokushige,Masashi Mizokami,Takaji Wakita +6 more
TL;DR: The genotype 2a subgenomic replicon was established in Huh7 cells and replicated efficiently with or without G418 selection in a transient replication assay, providing a powerful new tool for researching HCV.
Journal ArticleDOI
Sequence analysis of hepatitis C virus isolated from a fulminant hepatitis patient.
Takanobu Kato,Akihiro Furusaka,Michiko Miyamoto,Tomoko Date,Kotaro Yasui,Jun Hiramoto,Kazuo Nagayama,Teruji Tanaka,Takaji Wakita +8 more
TL;DR: HCV was isolated from a fulminant hepatitis patient and its entire genome was recovered; a clustering around genotype 2a was observed, but the sequence deviated especially in 5′UTR, core, NS3, and NS5A; and monoclonality of the HVR sequence was found not only in the fulminants hepatitis patient but in a certain percentage of chronic hepatitis patients.
Journal ArticleDOI
Hepatitis C virus JFH-1 strain infection in chimpanzees is associated with low pathogenicity and emergence of an adaptive mutation
Takanobu Kato,Takanobu Kato,Youkyung Choi,Gamal A. Elmowalid,Ronda K. Sapp,Heidi Barth,Akihiro Furusaka,Shunji Mishiro,Takaji Wakita,Krzysztof Krawczynski,T. Jake Liang +10 more
TL;DR: This study shows that the HCV JFH‐1 strain causes attenuated infection and low pathogenicity in chimpanzees and is capable of adapting in vivo with a unique mutation conferring an enhanced replicative phenotype.
Journal ArticleDOI
Association of insulin receptor substrate proteins with Bcl-2 and their effects on its phosphorylation and antiapoptotic function.
Hiroo Ueno,Eisaku Kondo,Ritsuko Yamamoto-Honda,Kazuyuki Tobe,Tetsuya Nakamoto,Ko Sasaki,Kinuko Mitani,Akihiro Furusaka,T. Tanaka,Yoshihide Tsujimoto,Takashi Kadowaki,Hisamaru Hirai +11 more
TL;DR: It is shown that IRS-1 associates with the loop domain of Bcl-2 and synergistically up-regulates antiapoptotic function of B Cl-2, thus regulating cell survival probably through regulating phosphorylation of B cl-2.
Journal ArticleDOI
Processing of hepatitis C virus core protein is regulated by its C-terminal sequence.
Takanobu Kato,Michiko Miyamoto,Akihiro Furusaka,Tomoko Date,Kotaro Yasui,Junko Kato,Shozo Matsushima,Tatsuji Komatsu,Takaji Wakita +8 more
TL;DR: Compared between clones isolated from two patients with fulminant hepatitis and from five patients with chronic hepatitis, the data suggest that core protein processing is regulated by C‐terminus mutations.