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Akihiro Kusumi
Researcher at Okinawa Institute of Science and Technology
Publications - 176
Citations - 17627
Akihiro Kusumi is an academic researcher from Okinawa Institute of Science and Technology. The author has contributed to research in topics: Membrane & Membrane protein. The author has an hindex of 63, co-authored 169 publications receiving 16344 citations. Previous affiliations of Akihiro Kusumi include Kyoto University & Kanagawa University.
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Journal ArticleDOI
Paradigm Shift of the Plasma Membrane Concept from the Two-Dimensional Continuum Fluid to the Partitioned Fluid: High-Speed Single-Molecule Tracking of Membrane Molecules
Akihiro Kusumi,Chieko Nakada,Ken Ritchie,K. Murase,Kenichi G. N. Suzuki,Hideji Murakoshi,Rinshi S. Kasai,Junko Kondo,Takahiro K. Fujiwara +8 more
TL;DR: The high-speed single-molecule tracking methods are described, and a new model of a partitioned fluid plasma membrane and the involvement of the actin-based membrane-skeleton "fences" and anchored-transmembrane protein "pickets" in the formation of compartment boundaries are critically reviewed.
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Confined lateral diffusion of membrane receptors as studied by single particle tracking (nanovid microscopy). Effects of calcium-induced differentiation in cultured epithelial cells.
TL;DR: In this article, the trajectories of E-cadherin, epidermal growth factor receptor, and transferrin receptor in the plasma membrane of a cultured mouse keratinocyte cell line were studied using both single particle tracking (SPT; nanovid microscopy) and fluorescence photobleaching recovery (FPR).
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Phospholipids undergo hop diffusion in compartmentalized cell membrane
TL;DR: It is proposed that various transmembrane proteins anchored to the actin-based membrane skeleton meshwork act as rows of pickets that temporarily confine phospholipids.
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The Ste20 group kinases as regulators of MAP kinase cascades
TL;DR: With the newly established phylogenetic relationships, crucial arguments can be advanced regarding the functions of these kinases as upstream activators of the MAPK pathways and possible activity as MAP4Ks.
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Ultrafine Membrane Compartments for Molecular Diffusion as Revealed by Single Molecule Techniques
K. Murase,Takahiro K. Fujiwara,Yasuhiro Umemura,Kenichi G. N. Suzuki,Ryota Iino,H. Yamashita,Mihoko Saito,Hideji Murakoshi,Ken Ritchie,Akihiro Kusumi +9 more
TL;DR: The results strongly indicate the necessity for the paradigm shift of the concept on the plasma membrane: from the two-dimensional fluid continuum model to the compartmentalized membrane model in which its constituent molecules undergo hop diffusion over the compartments.