A
Akiko Kuma
Researcher at Osaka University
Publications - 29
Citations - 6668
Akiko Kuma is an academic researcher from Osaka University. The author has contributed to research in topics: Autophagy & ATG5. The author has an hindex of 18, co-authored 28 publications receiving 5943 citations. Previous affiliations of Akiko Kuma include Graduate University for Advanced Studies & National Presto Industries.
Papers
More filters
Journal ArticleDOI
The role of autophagy during the early neonatal starvation period
Akiko Kuma,Masahiko Hatano,Makoto Matsui,Makoto Matsui,Akitsugu Yamamoto,Haruaki Nakaya,Tamotsu Yoshimori,Yoshinori Ohsumi,Takeshi Tokuhisa,Noboru Mizushima,Noboru Mizushima,Noboru Mizushima +11 more
TL;DR: The results suggest that the production of amino acids by autophagic degradation of ‘self’ proteins, which allows for the maintenance of energy homeostasis, is important for survival during neonatal starvation.
Journal ArticleDOI
Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate
Noboru Mizushima,Noboru Mizushima,Akiko Kuma,Akiko Kuma,Yoshinori Kobayashi,Yoshinori Kobayashi,Akitsugu Yamamoto,Masami Matsubae,Toshifumi Takao,Tohru Natsume,Yoshinori Ohsumi,Yoshinori Ohsumi,Tamotsu Yoshimori,Tamotsu Yoshimori,Tamotsu Yoshimori +14 more
TL;DR: It is demonstrated that the mouse Apg12-Apg5 conjugate forms a ∼800 kDa protein complex containing a novel WD-repeat protein, which is concluded to be the functional counterpart of the yeast Apg16.
Journal ArticleDOI
LC3, an autophagosome marker, can be incorporated into protein aggregates independent of autophagy: caution in the interpretation of LC3 localization.
TL;DR: It is shown that LC3 protein tends to aggregate in an autophagy-independent manner when it is transiently overexpressed by transfection, and it is demonstrated that punctate dots containing LC3 do not always represent autophagic structures.
Journal ArticleDOI
Autophagy Is Essential for Preimplantation Development of Mouse Embryos
TL;DR: After fertilization, maternal proteins in oocytes are degraded and new proteins encoded by the zygotic genome are synthesized, and autophagy, a process for the degradation of cytoplasmic constituents in the lysosome, plays a critical role during this period.
Journal ArticleDOI
Formation of the ∼350-kDa Apg12-Apg5·Apg16 Multimeric Complex, Mediated by Apg16 Oligomerization, Is Essential for Autophagy in Yeast
Akiko Kuma,Akiko Kuma,Noboru Mizushima,Noboru Mizushima,Naotada Ishihara,Yoshinori Ohsumi,Yoshinori Ohsumi +6 more
TL;DR: It is suggested that the Apg12-Apg5 conjugate and Apg16 form a multimeric complex mediated by theApg16 homo-oligomer, and formation of the ∼350-kDa complex is required for autophagy in yeast.