T
Tohru Natsume
Researcher at National Institute of Advanced Industrial Science and Technology
Publications - 204
Citations - 19551
Tohru Natsume is an academic researcher from National Institute of Advanced Industrial Science and Technology. The author has contributed to research in topics: Phosphorylation & Ubiquitin ligase. The author has an hindex of 56, co-authored 197 publications receiving 17217 citations. Previous affiliations of Tohru Natsume include Tokyo Metropolitan University.
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Journal ArticleDOI
Homeostatic Levels of p62 Control Cytoplasmic Inclusion Body Formation in Autophagy-Deficient Mice
Masaaki Komatsu,Satoshi Waguri,Masato Koike,Yu-shin Sou,Yu-shin Sou,Takashi Ueno,Taichi Hara,Noboru Mizushima,Junichi Iwata,Junichi Iwata,Junji Ezaki,Shigeo Murata,Jun Hamazaki,Yasumasa Nishito,Shun-ichiro Iemura,Tohru Natsume,Toru Yanagawa,Junya Uwayama,Eiji Warabi,Hiroshi Yoshida,Tetsuro Ishii,Akira Kobayashi,Masayuki Yamamoto,Zhenyu Yue,Yasuo Uchiyama,Eiki Kominami,Keiji Tanaka +26 more
TL;DR: The findings highlight the unexpected role of homeostatic level of p62, which is regulated by autophagy, in controlling intracellular inclusion body formation, and indicate that the pathologic process associated with autophagic deficiency is cell-type specific.
Journal ArticleDOI
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
Masaaki Komatsu,Hirofumi Kurokawa,Satoshi Waguri,Keiko Taguchi,Akira Kobayashi,Yoshinobu Ichimura,Yoshinobu Ichimura,Yu-shin Sou,Yu-shin Sou,Izumi Ueno,Ayako Sakamoto,Kit I. Tong,Mihee Kim,Yasumasa Nishito,Shun-ichiro Iemura,Tohru Natsume,Takashi Ueno,Eiki Kominami,Hozumi Motohashi,Keiji Tanaka,Masayuki Yamamoto +20 more
TL;DR: The findings indicate that the pathological process associated with p62 accumulation results in hyperactivation of Nrf2 and delineates unexpected roles of selective autophagy in controlling the transcription of cellular defence enzyme genes.
Journal ArticleDOI
Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy
Nao Hosokawa,Taichi Hara,Takeshi Kaizuka,Chieko Kishi,Akito Takamura,Yutaka Miura,Shun-ichiro Iemura,Tohru Natsume,Kenji Takehana,Naoyuki Yamada,Jun-Lin Guan,Noriko Oshiro,Noriko Oshiro,Noboru Mizushima +13 more
TL;DR: A novel mammalian autophagy factor, Atg13, is reported, which forms a stable approximately 3-MDa protein complex with ULK1 and FIP200, and suggests that mTORC1 suppressesAutophagy through direct regulation of the approximately 3,MDa ULK 1-Atg13-FIP200 complex.
Journal ArticleDOI
FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells
Taichi Hara,Akito Takamura,Chieko Kishi,Shun-ichiro Iemura,Tohru Natsume,Jun-Lin Guan,Noboru Mizushima +6 more
TL;DR: The results suggest that FIP200 is a novel mammalian autophagy factor that functions together with ULKs, which regulates diverse cellular functions such as cell size, proliferation, and migration.
Journal ArticleDOI
Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate
Noboru Mizushima,Noboru Mizushima,Akiko Kuma,Akiko Kuma,Yoshinori Kobayashi,Yoshinori Kobayashi,Akitsugu Yamamoto,Masami Matsubae,Toshifumi Takao,Tohru Natsume,Yoshinori Ohsumi,Yoshinori Ohsumi,Tamotsu Yoshimori,Tamotsu Yoshimori,Tamotsu Yoshimori +14 more
TL;DR: It is demonstrated that the mouse Apg12-Apg5 conjugate forms a ∼800 kDa protein complex containing a novel WD-repeat protein, which is concluded to be the functional counterpart of the yeast Apg16.