A
Akimasa Yasuda
Researcher at Keio University
Publications - 43
Citations - 1777
Akimasa Yasuda is an academic researcher from Keio University. The author has contributed to research in topics: Lumbar spinal stenosis & Spinal cord injury. The author has an hindex of 14, co-authored 36 publications receiving 1452 citations. Previous affiliations of Akimasa Yasuda include National Defense Medical College.
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Grafted human-induced pluripotent stem-cell–derived neurospheres promote motor functional recovery after spinal cord injury in mice
Satoshi Nori,Yohei Okada,Akimasa Yasuda,Osahiko Tsuji,Yuichiro Takahashi,Yoshiomi Kobayashi,Kanehiro Fujiyoshi,Masato Koike,Yasuo Uchiyama,Eiji Ikeda,Yoshiaki Toyama,Shinya Yamanaka,Masaya Nakamura,Hideyuki Okano +13 more
TL;DR: The findings suggest that hiPSCs give rise to neural stem/progenitor cells that support improved function post-SCI and are a promising cell source for its treatment.
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Pre-evaluated safe human iPSC-derived neural stem cells promote functional recovery after spinal cord injury in common marmoset without tumorigenicity
Yoshiomi Kobayashi,Yohei Okada,Go Itakura,Hiroki Iwai,Soraya Nishimura,Akimasa Yasuda,Satoshi Nori,Keigo Hikishima,Keigo Hikishima,Tsunehiko Konomi,Kanehiro Fujiyoshi,Osahiko Tsuji,Yoshiaki Toyama,Shinya Yamanaka,Masaya Nakamura,Hideyuki Okano +15 more
TL;DR: Results indicate that pre-evaluated safe hiPSC-NS/PCs are a potential source of cells for the treatment of SCI in the clinic.
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Time-dependent changes in the microenvironment of injured spinal cord affects the therapeutic potential of neural stem cell transplantation for spinal cord injury
Soraya Nishimura,Akimasa Yasuda,Hiroki Iwai,Morito Takano,Yoshiomi Kobayashi,Satoshi Nori,Osahiko Tsuji,Kanehiro Fujiyoshi,Hayao Ebise,Yoshiaki Toyama,Hideyuki Okano,Masaya Nakamura +11 more
TL;DR: To achieve functional recovery by NS/PC transplantation in cases at the chronic phase, modification of the microenvironment of the injured spinal cord focusing on glial scar formation and inflammatory phenotype should be considered.
Journal ArticleDOI
Significance of remyelination by neural stem/progenitor cells transplanted into the injured spinal cord.
Akimasa Yasuda,Osahiko Tsuji,Shinsuke Shibata,Satoshi Nori,Morito Takano,Yoshiomi Kobayashi,Yuichiro Takahashi,Kanehiro Fujiyoshi,Chikako Miyauchi Hara,Atsuhi Miyawaki,Hirotaka James Okano,Yoshiaki Toyama,Masaya Nakamura,Hideyuki Okano +13 more
TL;DR: The biological importance of remyelination by graft‐derived cells for functional recovery after the transplantation of NS/PCs into the injured spinal cord is established.
Journal ArticleDOI
Focal Transplantation of Human iPSC-Derived Glial-Rich Neural Progenitors Improves Lifespan of ALS Mice
Takayuki Kondo,Misato Funayama,Kayoko Tsukita,Akitsu Hotta,Akimasa Yasuda,Satoshi Nori,Shinjiro Kaneko,Masaya Nakamura,Ryosuke Takahashi,Hideyuki Okano,Shinya Yamanaka,Haruhisa Inoue +11 more
TL;DR: The results demonstrated the efficacy of cell therapy for ALS by the use of human iPSCs as cell source and suggested a potential therapeutic mechanism via activation of AKT signal.