Institution
Central Institute for Experimental Animals
Facility•Kawasaki, Japan•
About: Central Institute for Experimental Animals is a facility organization based out in Kawasaki, Japan. It is known for research contribution in the topics: Marmoset & Transplantation. The organization has 543 authors who have published 1155 publications receiving 33844 citations.
Papers published on a yearly basis
Papers
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TL;DR: It is suggested that multiple immunological dysfunctions, including cytokine production capability, in addition to functional incompetence of T, B, and NK cells, may lead to the high engraftment levels of xenograft in NOD/SCID/gamma(c)(null) mice.
1,382 citations
TL;DR: It is shown that replenishment of globular adiponectin may provide a novel treatment modality for both type 2 diabetes and atherosclerosis, and this is the first demonstration that globular leptin can protect against Atherosclerosis in vivo.
943 citations
TL;DR: It is concluded that both paracrine and endocrine effects of MCP-1 may contribute to the development of insulin resistance in aP2-M CP-1 mice.
854 citations
TL;DR: It is shown that neuroblast migration parallels cerebrospinal fluid (CSF) flow, and results suggest that polarized epithelial cells contribute important vectorial information for guidance of young, migrating neurons.
Abstract: In the adult brain, neuroblasts born in the subventricular zone migrate from the walls of the lateral ventricles to the olfactory bulb. How do these cells orient over such a long distance and through complex territories? Here we show that neuroblast migration parallels cerebrospinal fluid (CSF) flow. Beating of ependymal cilia is required for normal CSF flow, concentration gradient formation of CSF guidance molecules, and directional migration of neuroblasts. Results suggest that polarized epithelial cells contribute important vectorial information for guidance of young, migrating neurons.
763 citations
TL;DR: It is shown that the injection of a self-inactivating lentiviral vector in sucrose solution into marmoset embryos results in transgenic common marmosets that expressed the transgene in several organs.
Abstract: The common marmoset (Callithrix jacchus) is increasingly attractive for use as a non-human primate animal model in biomedical research. It has a relatively high reproduction rate for a primate, making it potentially suitable for transgenic modification. Although several attempts have been made to produce non-human transgenic primates, transgene expression in the somatic tissues of live infants has not been demonstrated by objective analyses such as polymerase chain reaction with reverse transcription or western blots. Here we show that the injection of a self-inactivating lentiviral vector in sucrose solution into marmoset embryos results in transgenic common marmosets that expressed the transgene in several organs. Notably, we achieved germline transmission of the transgene, and the transgenic offspring developed normally. The successful creation of transgenic marmosets provides a new animal model for human disease that has the great advantage of a close genetic relationship with humans. This model will be valuable to many fields of biomedical research.
652 citations
Authors
Showing all 543 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Hideyuki Okano | 128 | 1169 | 67148 |
| Katsuhiko Mikoshiba | 120 | 866 | 62394 |
| Akira Kikuchi | 93 | 412 | 28893 |
| Atsushi Miyajima | 89 | 360 | 27705 |
| Tatsutoshi Nakahata | 77 | 466 | 24761 |
| Kazuo Sugamura | 76 | 260 | 20946 |
| Hiroshi Yamazaki | 74 | 953 | 27216 |
| Yoshio Koyanagi | 57 | 247 | 14514 |
| Motoya Katsuki | 57 | 129 | 14504 |
| Mamoru Ito | 56 | 236 | 11495 |
| Mingjiang Xu | 54 | 190 | 9703 |
| Yasushi Yamazoe | 53 | 285 | 9703 |
| Toshio Heike | 50 | 267 | 11422 |
| Kiyoshi Ando | 46 | 318 | 9414 |
| Jun-ichi Hata | 46 | 243 | 10101 |