Y
Yoshiaki Toyama
Researcher at Keio University
Publications - 682
Citations - 36071
Yoshiaki Toyama is an academic researcher from Keio University. The author has contributed to research in topics: Spinal cord injury & Spinal cord. The author has an hindex of 89, co-authored 681 publications receiving 32359 citations. Previous affiliations of Yoshiaki Toyama include Niigata University & Wakayama Medical University.
Papers
More filters
Journal ArticleDOI
Identification and characterization of a novel protein, periostin, with restricted expression to periosteum and periodontal ligament and increased expression by transforming growth factor β
Keisuke Horiuchi,Norio Amizuka,Sunao Takeshita,Hiroyuki Takamatsu,Mieko Katsuura,Hidehiro Ozawa,Yoshiaki Toyama,Lynda F. Bonewald,Akira Kudo +8 more
TL;DR: Immunohistochemistry and reverse transcription‐ polymerase chain reaction analysis suggest that periostin may play a role in the recruitment and attachment of osteoblast precursors in theperiosteum.
Journal ArticleDOI
Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury.
Seiji Okada,Masaya Nakamura,Hiroyuki Katoh,Tamaki Miyao,Takuya Shimazaki,Ken Ishii,Junichi Yamane,Akihiko Yoshimura,Yukihide Iwamoto,Yoshiaki Toyama,Hideyuki Okano +10 more
TL;DR: It is suggested that Stat3 is a key regulator of reactive astrocytes in the healing process after SCI, providing a potential target for intervention in the treatment of CNS injury.
Journal ArticleDOI
DC-STAMP is essential for cell–cell fusion in osteoclasts and foreign body giant cells
Mitsuru Yagi,Takeshi Miyamoto,Yumi Sawatani,Katsuya Iwamoto,Naobumi Hosogane,Nobuyuki Fujita,Kozo Morita,Ken Ninomiya,Toru Suzuki,Kana Miyamoto,Yuichi Oike,Motohiro Takeya,Yoshiaki Toyama,Toshio Suda +13 more
TL;DR: An essential regulator of osteoclast and macrophage cell fusion, DC-STAMP, is identified and an essential role of osteOClast multinucleation in bone homeostasis is identified.
Journal ArticleDOI
The effect of calcium ion concentration on osteoblast viability, proliferation and differentiation in monolayer and 3D culture.
Shinichi Maeno,Yasuo Niki,Hideo Matsumoto,Hideo Morioka,Taku Yatabe,Atsushi Funayama,Yoshiaki Toyama,Tetsushi Taguchi,Junzo Tanaka +8 more
TL;DR: The present results indicate that 2-4 mM Ca2+ is suitable for proliferation and survival of osteoblasts, whereas slightly higher concentrations (6-8 mM) favor osteoblast differentiation and matrix mineralization in both 2- and 3-dimensional cultures.
Journal ArticleDOI
Transplantation of in vitro‐expanded fetal neural progenitor cells results in neurogenesis and functional recovery after spinal cord contusion injury in adult rats
Yuto Ogawa,Kazunobu Sawamoto,Kazunobu Sawamoto,Takaki Miyata,Sachiyo Miyao,Masahiko Watanabe,Masaya Nakamura,Barbara S. Bregman,Masato Koike,Yasuo Uchiyama,Yoshiaki Toyama,Hideyuki Okano +11 more
TL;DR: Evidence that in vitro‐expanded fetus‐derived neurosphere cells were able to generate neurons in vivo and improve motor function upon transplantation into an adult rat spinal‐cord‐contusion injury model is presented.