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Akira Endo
Researcher at Tokyo University of Agriculture
Publications - 102
Citations - 6938
Akira Endo is an academic researcher from Tokyo University of Agriculture. The author has contributed to research in topics: Reductase & Enzyme. The author has an hindex of 35, co-authored 101 publications receiving 6651 citations.
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Inhibitory Effects on Lipid Metabolismn in Cultured Cells of ML‐236B, a Potent Inhibitor of 3‐Hydroxt‐3‐methylglutaryl‐Cornzyme‐A Reductase
TL;DR: It is concluded slight activity of endogenous sterol synthesis, which provides enfogenous copounds generated from meavalonate, may be essential to the growth of cells even when sufficeient amounts of cholesterol are availavel to the cells.
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Monacolin k, a new hypocholesterolemic agent that specifically inhibits 3-hydroxy-3-methylglutaryl coenzyme a reductase
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Therapeutic effects of ML-236B in primary hypercholesterolemia
TL;DR: ML-236B, a competitive inhibitor of 3-hydroxy-3-methylglutaryl CoA reductase, was administered to 11 patients with primary hypercholesterolemia and saw a marked reduction in tuberous xanthomas, but here the drug was less effective in reducing the serum cholesterol level and a higher dose was required for treatment.
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