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Akshay Pandey
Researcher at University of Illinois at Chicago
Publications - 8
Citations - 195
Akshay Pandey is an academic researcher from University of Illinois at Chicago. The author has contributed to research in topics: FOXM1 & FOXA2. The author has an hindex of 6, co-authored 8 publications receiving 155 citations.
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Journal ArticleDOI
Essential roles of FoxM1 in Ras-induced liver cancer progression and in cancer cells with stem cell features
Dragana Kopanja,Akshay Pandey,Megan M. Kiefer,Zebin Wang,Neha Chandan,Janai R. Carr,Janai R. Carr,Roberta Franks,Dae Yeul Yu,Grace Guzman,Ajay V. Maker,Pradip Raychaudhuri,Pradip Raychaudhuri +12 more
TL;DR: Genetic evidence is provided for an essential role of FoxM1 in the progression of Ras-driven HCC and in the survival of the HCC cells with stem cell features by regulating ROS.
Journal ArticleDOI
An improved non-enzymatic “DNA ladder assay” for more sensitive and early detection of apoptosis
TL;DR: This study demonstrates a rapid, easy-to-perform cost-effective method for detection of apoptotic DNA fragments with considerable improvement in the sensitivity by avoiding loss of DNA fragments.
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Opposing Roles of the Forkhead Box Factors FoxM1 and FoxA2 in Liver Cancer
Vaibhav Chand,Akshay Pandey,Dragana Kopanja,Grace Guzman,Pradip Raychaudhuri,Pradip Raychaudhuri +5 more
TL;DR: FoxM1 drives high-grade HCC progression partly by inhibiting the hepatocyte differentiation gene FoxA2, and the observations provide strong genetic evidence for an opposing role of FoxM1 and FoxA1 in H CC progression.
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Radioresistant Sf9 insect cells undergo an atypical form of Bax-dependent apoptosis at very high doses of γ-radiation
Sudhir Chandna,Shubhankar Suman,Mauli Chandna,Akshay Pandey,V. N. Singh,Ashok Kumar,Bilikere S. Dwarakanath,Rakesh Kumar Seth +7 more
TL;DR: This study demonstrates that the Sf9 insect cells display good homology with human cells in the mitochondria-dependent events during radiation-induced apoptosis, although doses eliciting similar responses were 50–200 times higher than human cells.
Journal ArticleDOI
Plk1 Regulates the Repressor Function of FoxM1b by inhibiting its Interaction with the Retinoblastoma Protein.
Nishit K. Mukhopadhyay,Vaibhav Chand,Akshay Pandey,Dragana Kopanja,Janai R. Carr,Yi Ju Chen,Xiubei Liao,Pradip Raychaudhuri,Pradip Raychaudhuri +8 more
TL;DR: The results show that the Plk1 phosphorylation sites in FoxM1b serve as a regulator for its repressor function, and they provide insights into how FoxM 1b inhibits differentiation genes and activates proliferation genes during cancer progression.