Alain Dessein

TL;DR: To localize this gene, referred to as SM1, a genome-wide study on 142 Brazilian subjects belonging to 11 informative families showed a linkage to only one region, on chromosome 5q31–q33, with maximum two-point lod scores, indicating a close proximity to CSF1R as the most likely location of SM1.

TL;DR: Observations can be taken as evidence supporting a role of IgE in human resistance to infection by S. mansoni.

TL;DR: It is shown that Leishmania donovani stimulates the differentiation of Th17 cells, which produce IL-17, IL-22, and IFN-gamma, which play complementary roles in human protection against KA, and that a defect in Th17 induction may increase the risk of KA.

TL;DR: Results show that infection levels and advanced hepatic fibrosis in human schistosomiasis are controlled by distinct loci; they suggest that polymorphisms within the IFN-gammaR1 gene could determine severe hepatic disease due to S. mansoni infection and that theIFN-GammaR 1 gene is a strong candidate for the control of abnormal fibrosis observed in other diseases.

TL;DR: Findings indicate that a number of conserved proteins may be major targets of host-protective immunity against S. mansoni and the hypothesis is discussed that genetic restriction of the immune response to these antigens may occur in heterogeneous human populations because of the limited number of T cell epitopes carried by these host-like proteins.